It really depends what you started with - I've never touched 6502, but I did a lot of z80 assembly back in the day. Since Zilog was started by ex-Intel people

It really depends what you started with - I've never touched 6502, but I did a lot of z80 assembly back in the day. Since Zilog was started by ex-Intel people there's a lot in common. For me jumping from z80 -> x86 was only a small change. The same notion of paired-registers and very similar instructions made it a simple enough change. Of course these days there have been a lot of changes, but the basics are still basic, albeit idiosyncratic.