Yes, I think the most practical scenarios this would fail in the real world would be: 1) Signed binaries or other similar concepts such as "anti-cheat" stuff t

Yes, I think the most practical scenarios this would fail in the real world would be: 1) Signed binaries or other similar concepts such as "anti-cheat" stuff that tries to detect binary modification. 2) Code that actually does do really weird stuff in order to fool static disassembly, e.g., obfuscation which is not uncommon in games and some other binary types. Of course, if you created the binary yourself, you'd be aware of all these gotchas, so this would only come as a surprise if you were applying it as a "third party" to some arbitrary binary.