Although I personally prefer Guix, I too would like to be able to quickly and transparently replicate an environment on a remote machine and run a program there

Although I personally prefer Guix, I too would like to be able to quickly and transparently replicate an environment on a remote machine and run a program there. But then there is still the problem of the input and output files, so the FUSE filesystem is still a really great idea. I think we could use outrun as a basis for such a tool, since it solves most of the problem already.