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> If you could do that, you unlock a massive amount of science around how mitochondria function Note that 99% of the proteins contained in mitochondria are [co
by est31 6y ago
> If you could do that, you unlock a massive amount of science around how mitochondria function
Note that 99% of the proteins contained in mitochondria are [coded] in the nucleus, only 1% is [coded] in the mitochondrial chromosome. It's extremely small, only containing 37 genes of which most are related to translation (but of course translation requires far more, e.g. elongation factors).
https://www.nature.com/articles/nrm2959 https://www.nature.com/articles/nrm2959
- reubenswartz 6y agoI get what you're saying, but I think you have a typo in there. Most of the proteins in the mitochondria are coded by nuclear DNA, but the proteins themselves end up in the mitochondria.
- est31 6y agoThanks! Edited.
- Cieplak 6y agoThe number of genes encoded in the mitochondrial chromosome, 37, reminds me of the 29 states in Von Neumann’s universal constructor [1]. [1] https://en.wikipedia.org/wiki/Von_Neumann_universal_constructor https://en.wikipedia.org/wiki/Von_Neumann_universal_construc...
- koeng 6y agoI guess that was a bit of a hyperbole. You can learn more about the mitochondria genetically engineering the nucleus, but the main problem is that there still is science to be done on the mitochondrial genome that is "locked" down by not being able to transform it, especially when it comes to stuff like how translation works within those mitochondria.