For me, the main difference is that Fedora packages are close to the upstream code, while Debian makes heavy and sometimes controversial changes (remember Icewe

For me, the main difference is that Fedora packages are close to the upstream code, while Debian makes heavy and sometimes controversial changes (remember Iceweasel?). In an ideal world I would use Flatpak for everything -- code direct from upstream, decoupled from the base system.