4 ms·

Imagine if people die en masse 6 months later? or even if they don't die, they could develop many kinds of problems; that's why testing vaccines must take time

Imagine if people die en masse 6 months later? or even if they don't die, they could develop many kinds of problems; that's why testing vaccines must take time and procedure, it doesn't seem to be the case here..

Miner49er 6y ago
I'm not a doctor, but I'm curious how likely that is? It seems to me that with a vaccine most problems would show up quickly after receiving the vaccine, but I imagine we do testing the way we do for a reason. Does anyone know of examples of failed vaccines that caused problems months after receiving it? Edit: Found some: https://www.aamc.org/news-insights/here-s-why-we-can-t-rush-covid-19-vaccine https://www.aamc.org/news-insights/here-s-why-we-can-t-rush-... Although some of these seem to be production errors.
- gregoriol 6y ago
  There was for example research not so long ago about an H1N1 vaccine and cases of narcolepsy: it seems it was finally determined that the vaccine is not a cause, but it was important to verify (https://www.cdc.gov/vaccinesafety/concerns/history/narcolepsy-flu.html https://www.cdc.gov/vaccinesafety/concerns/history/narcoleps... https://en.wikipedia.org/wiki/Pandemrix#Narcolepsy_investigations https://en.wikipedia.org/wiki/Pandemrix#Narcolepsy_investiga...)
  - vesinisa 6y ago
    No, the Pandemrix vaccine was almost certainly the cause of the narcolepsy epidemic in Finland and Sweden in 2009-2013. The case seems to have been a very unfortunate coincidence of a specific booster used in this vaccine (squalene), genetic susceptibility of the population (large incidence of a specific autoimmunity mutation), and one protein in this specific vaccine evoking an autoimmune reaction against orexin-producing neurons in the brain. Orexin is a naturally occurring hormone in our bodies that regulates wakefulness, and the lack of which is the cause of type I narcolepsy. My understanding is had any one of these three unfortunate factors (the bad booster, the bad population genetics, or the bad protein) been removed, the vaccine would have likely been safe. Further, only children and adolescents were ever susceptible to the harmful side effect. The specific vaccine (Pandemrix) was not used in the United States, as the CDC notes.
- gus_massa 6y ago
  One of the risk is Antibody-dependent enhancement https://en.wikipedia.org/wiki/Antibody-dependent_enhancement https://en.wikipedia.org/wiki/Antibody-dependent_enhancement > ADE has been observed in both severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) animal models allowing the respective viruses to enter cells expressing Fc𝛾R including myeloid lineage cells. Those virus are similar enough to be cautious, and test the covid-19 vaccine carefully.

Miner49er 6y ago

I'm not a doctor, but I'm curious how likely that is? It seems to me that with a vaccine most problems would show up quickly after receiving the vaccine, but I imagine we do testing the way we do for a reason. Does anyone know of examples of failed vaccines that caused problems months after receiving it? Edit: Found some: https://www.aamc.org/news-insights/here-s-why-we-can-t-rush-covid-19-vaccine https://www.aamc.org/news-insights/here-s-why-we-can-t-rush-... Although some of these seem to be production errors.

gregoriol 6y ago
There was for example research not so long ago about an H1N1 vaccine and cases of narcolepsy: it seems it was finally determined that the vaccine is not a cause, but it was important to verify (https://www.cdc.gov/vaccinesafety/concerns/history/narcolepsy-flu.html https://www.cdc.gov/vaccinesafety/concerns/history/narcoleps... https://en.wikipedia.org/wiki/Pandemrix#Narcolepsy_investigations https://en.wikipedia.org/wiki/Pandemrix#Narcolepsy_investiga...)
- vesinisa 6y ago
  No, the Pandemrix vaccine was almost certainly the cause of the narcolepsy epidemic in Finland and Sweden in 2009-2013. The case seems to have been a very unfortunate coincidence of a specific booster used in this vaccine (squalene), genetic susceptibility of the population (large incidence of a specific autoimmunity mutation), and one protein in this specific vaccine evoking an autoimmune reaction against orexin-producing neurons in the brain. Orexin is a naturally occurring hormone in our bodies that regulates wakefulness, and the lack of which is the cause of type I narcolepsy. My understanding is had any one of these three unfortunate factors (the bad booster, the bad population genetics, or the bad protein) been removed, the vaccine would have likely been safe. Further, only children and adolescents were ever susceptible to the harmful side effect. The specific vaccine (Pandemrix) was not used in the United States, as the CDC notes.
gus_massa 6y ago
One of the risk is Antibody-dependent enhancement https://en.wikipedia.org/wiki/Antibody-dependent_enhancement https://en.wikipedia.org/wiki/Antibody-dependent_enhancement > ADE has been observed in both severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) animal models allowing the respective viruses to enter cells expressing Fc𝛾R including myeloid lineage cells. Those virus are similar enough to be cautious, and test the covid-19 vaccine carefully.