3 ms·

Have you tried diphenhydramine? It helps me a lot work occasional insomnia and I never feel groggy the next day. I also started taking 1mg melatonin an hour be

Have you tried diphenhydramine? It helps me a lot work occasional insomnia and I never feel groggy the next day. I also started taking 1mg melatonin an hour before I want to sleep. That works wonders for me. https://slatestarcodex.com/2018/07/10/melatonin-much-more-than-you-wanted-to-know/ https://slatestarcodex.com/2018/07/10/melatonin-much-more-th... ... and, umm, mindfulness, I guess.

newsbinator 6y ago
For those people who feel groggy or nauseous/headachy in the morning after Melatonin, try taking 0.3mg. You might find it has the same effect with less pronounced side effects. (I am not a doctor)
- esperent 6y ago
  I have tested different doses quite a bit. 5mg makes me feel groggy the next day. <0.5mg seems to do morning. ~1mg seems like the sweet spot for me.
btrettel 6y ago
I'd recommend against regularly taking anticholinergic drugs like diphenhydramine because they've been fairly clearly linked to cognitive decline in the elderly when taken regularly: https://en.wikipedia.org/wiki/Diphenhydramine#Adverse_effects https://en.wikipedia.org/wiki/Diphenhydramine#Adverse_effect... It's worth noting that many allergy meds (like diphenhydramine) are anticholinergic, but only ones which pass the blood-brain barrier are linked to cognitive decline. So newer allergy meds like cetirizine and loratadine are better.
- esperent 6y ago
  Your link says anticholinergic use later in life has been linked to cognitive decline, not that use by young people results in cognitive decline later in life.
  - btrettel 6y ago
    I linked to Wikipedia, but I originally read the abstract of a different study, which might have examined diphenhydramine specifically rather than many anticholinergic drugs. The abstract of the article cited on Wikipedia makes it clear that it's a cumulative effect, and that they studied outcomes in older adults. So I think Wikipedia describes the research incorrectly. https://pubmed.ncbi.nlm.nih.gov/25879993/ https://pubmed.ncbi.nlm.nih.gov/25879993/

newsbinator 6y ago

For those people who feel groggy or nauseous/headachy in the morning after Melatonin, try taking 0.3mg. You might find it has the same effect with less pronounced side effects. (I am not a doctor)

esperent 6y ago
I have tested different doses quite a bit. 5mg makes me feel groggy the next day. <0.5mg seems to do morning. ~1mg seems like the sweet spot for me.

btrettel 6y ago

I'd recommend against regularly taking anticholinergic drugs like diphenhydramine because they've been fairly clearly linked to cognitive decline in the elderly when taken regularly: https://en.wikipedia.org/wiki/Diphenhydramine#Adverse_effects https://en.wikipedia.org/wiki/Diphenhydramine#Adverse_effect... It's worth noting that many allergy meds (like diphenhydramine) are anticholinergic, but only ones which pass the blood-brain barrier are linked to cognitive decline. So newer allergy meds like cetirizine and loratadine are better.

esperent 6y ago
Your link says anticholinergic use later in life has been linked to cognitive decline, not that use by young people results in cognitive decline later in life.
- btrettel 6y ago
  I linked to Wikipedia, but I originally read the abstract of a different study, which might have examined diphenhydramine specifically rather than many anticholinergic drugs. The abstract of the article cited on Wikipedia makes it clear that it's a cumulative effect, and that they studied outcomes in older adults. So I think Wikipedia describes the research incorrectly. https://pubmed.ncbi.nlm.nih.gov/25879993/ https://pubmed.ncbi.nlm.nih.gov/25879993/