4 ms·

Intuition can die often, but on the other hand many individual processes within immunology are somewhat well characterized as far as biology goes, and are amazi

Intuition can die often, but on the other hand many individual processes within immunology are somewhat well characterized as far as biology goes, and are amazing. The VDJ recombination process for B and T cell development is a stochastic-engineering-like feat of self-driven mutation (not just slight code changes but actually chopping up parts of our DNA and rearranging their order) and is occurring constantly in huge numbers of developing lymphocytes to generate structurally new proteins under very close scrutiny, allowing our immune system to adapt to previously unseen infections. https://en.m.wikipedia.org/wiki/V(D)J_recombination https://en.m.wikipedia.org/wiki/V(D)J_recombination

deleted 6y ago
[deleted]
bionhoward 6y ago
It’s amazing to watch folks deny evolution while their bodies evolve new immunity in real time
- Terr_ 6y ago
  The Long-Term E-Coli Experiment [0] is also pretty awesome, because not only is is evolution seen directly in the lab, but frozen samples can reveal exactly what steps turned out to be important. [0] https://en.wikipedia.org/wiki/E._coli_long-term_evolution_experiment https://en.wikipedia.org/wiki/E._coli_long-term_evolution_ex...
  - pas 6y ago
    https://www.youtube.com/watch?v=yybsSqcB7mE https://www.youtube.com/watch?v=yybsSqcB7mE (Harvard Mega-Dish antibiotic experiment)
- kevinmchugh 6y ago
  The most sophisticated arguers of that group would draw a distinction between short-term evolution and long-term. This was normally a response to the peppered moth observations. That's short-term evolution, which doesn't explain ball and socket joints, or eyes. Or, this was the explanation on blogs 10-15 years ago. A very strange time that was.
autisticcurio 6y ago
I've come to the conclusion the "immunologists" dont know enough and for a very good reason, we are unable to quantify what each and every cell contains chemically and we are unable to measure cell sensing and signally in vivo. So we dont know when a number of cells surrounding a damaged cell or pathogen are using the hydroxyl radical, arguably the most dangerous of the free radicals, to destroy or damage the damaged cell or pathogen. As we get older, we maintain the ability to sense pathogens in the adaptive immune system, but we fail to launch a suitable response. Studies also show, flu vaccines are a waste of time if the person doesnt have a sufficient amount of B6 in their diet in order for the body to develop an immune system response. In my experience GP's never ask about our diets, they make assumptions and this is dangerous to our health. Now does osteoporosis play its part in a weaken immune system response because the quality of stem cells from the bone marrow is greatly reduced? Not found any studies looking at this angle yet. What about Vitamin D3, the Wellcome Trust in Cambridge announced it had reversed engineered the human genome in Aug 2010, and from the research they found that there were 2776 Vit D Receptors in the human genome, most of which are concentrated around the immune system genes, so how significant is Vit D in immune system responses? How much does Iron in the diet play a part, for example, there is a chemical reaction in the gut which can reduce Ferric iron (State3) into Ferrous iron (State2) before its absorbed, how much does dietary iron and exercise generating hydroxyl radicals play a part in innate immunology? The hydroxyl radical is generally portrayed as a very damaging chemical reaction, yet we do get told to exercise. Likewise what about water only Fasting? When looking at Lysine, its one of only two keto BC amino acids, used to treat cold sores (Herpes) as its been suggested viruses at least the Herpes virus need carbs. Bacteria can die off when there is inadequate nutrition, but they can also go dormant in the body by developing a biofilm. So even though immune cell counts go down when water only fasting, as its no longer having to attack most of the food and drink we consume, does the process of starving of viruses and bacteria make the remaining immune system cells more effective as its only having to concentrated on pathogens in the body. I'd agree with the article in that immunology is a complex topic, but our lack of high tech scientific instruments limit our knowledge forcing the use of meta data to make conclusions and judgements, and the spooks know all too well that they can get it wrong!

deleted 6y ago

[deleted]

bionhoward 6y ago

It’s amazing to watch folks deny evolution while their bodies evolve new immunity in real time

Terr_ 6y ago
The Long-Term E-Coli Experiment [0] is also pretty awesome, because not only is is evolution seen directly in the lab, but frozen samples can reveal exactly what steps turned out to be important. [0] https://en.wikipedia.org/wiki/E._coli_long-term_evolution_experiment https://en.wikipedia.org/wiki/E._coli_long-term_evolution_ex...
- pas 6y ago
  https://www.youtube.com/watch?v=yybsSqcB7mE https://www.youtube.com/watch?v=yybsSqcB7mE (Harvard Mega-Dish antibiotic experiment)
kevinmchugh 6y ago
The most sophisticated arguers of that group would draw a distinction between short-term evolution and long-term. This was normally a response to the peppered moth observations. That's short-term evolution, which doesn't explain ball and socket joints, or eyes. Or, this was the explanation on blogs 10-15 years ago. A very strange time that was.

autisticcurio 6y ago

I've come to the conclusion the "immunologists" dont know enough and for a very good reason, we are unable to quantify what each and every cell contains chemically and we are unable to measure cell sensing and signally in vivo. So we dont know when a number of cells surrounding a damaged cell or pathogen are using the hydroxyl radical, arguably the most dangerous of the free radicals, to destroy or damage the damaged cell or pathogen. As we get older, we maintain the ability to sense pathogens in the adaptive immune system, but we fail to launch a suitable response. Studies also show, flu vaccines are a waste of time if the person doesnt have a sufficient amount of B6 in their diet in order for the body to develop an immune system response. In my experience GP's never ask about our diets, they make assumptions and this is dangerous to our health. Now does osteoporosis play its part in a weaken immune system response because the quality of stem cells from the bone marrow is greatly reduced? Not found any studies looking at this angle yet. What about Vitamin D3, the Wellcome Trust in Cambridge announced it had reversed engineered the human genome in Aug 2010, and from the research they found that there were 2776 Vit D Receptors in the human genome, most of which are concentrated around the immune system genes, so how significant is Vit D in immune system responses? How much does Iron in the diet play a part, for example, there is a chemical reaction in the gut which can reduce Ferric iron (State3) into Ferrous iron (State2) before its absorbed, how much does dietary iron and exercise generating hydroxyl radicals play a part in innate immunology? The hydroxyl radical is generally portrayed as a very damaging chemical reaction, yet we do get told to exercise. Likewise what about water only Fasting? When looking at Lysine, its one of only two keto BC amino acids, used to treat cold sores (Herpes) as its been suggested viruses at least the Herpes virus need carbs. Bacteria can die off when there is inadequate nutrition, but they can also go dormant in the body by developing a biofilm. So even though immune cell counts go down when water only fasting, as its no longer having to attack most of the food and drink we consume, does the process of starving of viruses and bacteria make the remaining immune system cells more effective as its only having to concentrated on pathogens in the body. I'd agree with the article in that immunology is a complex topic, but our lack of high tech scientific instruments limit our knowledge forcing the use of meta data to make conclusions and judgements, and the spooks know all too well that they can get it wrong!