4 ms·

This is basically filtering the plasma to remove harmful stuff, which is present in the older mice but not the younger. That's probably because the older mice's

This is basically filtering the plasma to remove harmful stuff, which is present in the older mice but not the younger. That's probably because the older mice's liver and kidneys aren't as effective as they used to be. The conjoined experiment worked because the young mouses liver and kidneys were filtering for both of the mice. This sort of filtering (which includes albumin replacement) is already available for humans. My ex-wife was hospitalized when her liver failed. Her blood was full of toxins, which overwhelmed her kidneys and eventually caused them to fail too. The toxins in the blood had a lot of bad effects, and would have killed her. While she was waiting for a liver donation, she had to undergo blood dialysis pretty much every day. She was hooked up to a machine that pumped her blood out, filtered it, replaced albumin (which was lost in the filter), and then pumped it back in. Each treatment took about two hours, and was really stressful and dangerous. Her blood pressure had to be carefully managed, and the machine couldn't keep her blood at the exactly correct temperature so it ached when going back in. Bad as it was, it kept her blood clean enough for her to hang on until she got a transplant. She was on kidney dialysis for a year after that until she got a kidney transplant too. This was incredibly expensive, because of the albumin. Also incredibly dangerous. You would not want to do this as an elective procedure.

autisticcurio 6y ago
One of my ex bosses had a liver transplant and it meant the rest of his life was spent consuming pills to prevent his immune system from attack the donor liver. I only found this out when I asked a colleague why did he smell funny. Having tried raw liver myself and experiencing the stimulating energising effects compared to cooked liver, I wonder how much folded proteins created by cooking food contributes its own problems. In some cases, if a folded protein gets into a cell, the only remedy for the cell is to have the immune system destroy it. That puts a demand on stem cell generation to fill the void. Its been suggested sweating is the 3rd kidney and that spending 15mins in a 80DegreesC sauna can sweat more toxins than the kidneys can excrete in a 24hr period. Its looking like our sedentary air conditioned office lifestyles could be more harmful than we first thought. I have found it interesting that Methylation is now being looked at as another form of antioxidant process especially when considering its relationship to cancer progression. When looking at the methylation processes, its clear even the most organic of diets dont contain enough molecules for us humans to maintain healthy methylation, probably because the host animal or plant needs the same molecule to maintain its own life, thus leaving little else for us to use. What constitutes "essential" nutrients is certainly being reconsidered now a days.
epicureanideal 6y ago
I think the medical care or something else was expensive. I did a search and I see 20% albumin solution was about $8 per 50ml. https://www.drugs.com/price-guide/human-albumin-grifols https://www.drugs.com/price-guide/human-albumin-grifols I searched and apparently there’s about 3 liters of plasma in the body. So that’s only about $480 for a full replacement of the body’s plasma, or $240 for what this research did. It’s probably more expensive because of the machine for filtering the blood and so on. But it doesn’t seem that the raw materials for the replacement solution are expensive.
- jolmg 6y ago
  It would seem to be a pretty big factor if I'm reading correctly that it'd be $480/day.

autisticcurio 6y ago

One of my ex bosses had a liver transplant and it meant the rest of his life was spent consuming pills to prevent his immune system from attack the donor liver. I only found this out when I asked a colleague why did he smell funny. Having tried raw liver myself and experiencing the stimulating energising effects compared to cooked liver, I wonder how much folded proteins created by cooking food contributes its own problems. In some cases, if a folded protein gets into a cell, the only remedy for the cell is to have the immune system destroy it. That puts a demand on stem cell generation to fill the void. Its been suggested sweating is the 3rd kidney and that spending 15mins in a 80DegreesC sauna can sweat more toxins than the kidneys can excrete in a 24hr period. Its looking like our sedentary air conditioned office lifestyles could be more harmful than we first thought. I have found it interesting that Methylation is now being looked at as another form of antioxidant process especially when considering its relationship to cancer progression. When looking at the methylation processes, its clear even the most organic of diets dont contain enough molecules for us humans to maintain healthy methylation, probably because the host animal or plant needs the same molecule to maintain its own life, thus leaving little else for us to use. What constitutes "essential" nutrients is certainly being reconsidered now a days.

epicureanideal 6y ago

I think the medical care or something else was expensive. I did a search and I see 20% albumin solution was about $8 per 50ml. https://www.drugs.com/price-guide/human-albumin-grifols https://www.drugs.com/price-guide/human-albumin-grifols I searched and apparently there’s about 3 liters of plasma in the body. So that’s only about $480 for a full replacement of the body’s plasma, or $240 for what this research did. It’s probably more expensive because of the machine for filtering the blood and so on. But it doesn’t seem that the raw materials for the replacement solution are expensive.

jolmg 6y ago
It would seem to be a pretty big factor if I'm reading correctly that it'd be $480/day.