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That is possible but the large sample size may help. The study involved roughly a half million people with around one hundred thousand supplementing with gluco
by m0llusk 6y ago
That is possible but the large sample size may help. The study involved roughly a half million people with around one hundred thousand supplementing with glucosamine. With that many people and these big numbers the results are rather strong.
- dahinds 6y agoIn large studies, both true causal and true non-causal associations get stronger -- size gives no protection from confounding.
- Obi_Juan_Kenobi 6y agoSampling addresses variance, not confounding factors. If the sample is not representative of the broader population, then in no way will any amount of sampling correct that error. Observational studies often involve quite large samples, but they remain unreliable because it is extremely difficult to address all possible confounding factors. Experimental intervention is the gold standard for a reason, and absent the ethical or practical impossibility of experimentation, should be used here.