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If you are interested in digging into this stuff, and what really works medically/scientifically based on reviewed evidence and sources such as Cochrane Reviews

by evo_9 6y ago

If you are interested in digging into this stuff, and what really works medically/scientifically based on reviewed evidence and sources such as Cochrane Reviews, I can't recommend Dr Stanfields youtube channel high enough: https://www.youtube.com/c/DrBradStanfield/videos https://www.youtube.com/c/DrBradStanfield/videos Also here is his video on Sulforaphane which Glucosamine activates. He goes into detail as to how this mechanism works. Because of his video/latest research presented I changed to taking Broccomax because you need Myrosinase to actvite the SGS for it's full effect, he goes into detail on this here: https://www.youtube.com/watch?v=qAb1eQbRAe0 https://www.youtube.com/watch?v=qAb1eQbRAe0 Cochrane Review he uses as his primary source: https://www.cochrane.org/CD007176/LIVER_antioxidant-supplements-for-prevention-of-mortality-in-healthy-participants-and-patients-with-various-diseases https://www.cochrane.org/CD007176/LIVER_antioxidant-suppleme...

hkt 6y ago
Is a Cochrane review really a primary source? They're meta-analysis, which I'd think of as secondary. In the case linked, the analysis seems pretty unequivocally to not support supplementing: "We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality, and so may higher doses of vitamin A. Antioxidant supplements need to be considered as medicinal products and should undergo sufficient evaluation before marketing." Did I miss something?
- DiabloD3 6y ago
  Vitamin E research also ends up being a bit YMMV: most commercially available Vitamin E is one form only, alpha tocopherol... except Vit E is 8 different forms: 4 tocopherols and 4 tocotrienols. The research that has been done so far basically indicates alpha tocopherol-only supplementation aligns identically with unspecified-Vitamin-E-is-bad research.
- JamesBarney 6y ago
  The op talks about sulforaphane but then links to an article about vitamin a and e(I don't know why) They're totally different chemicals that work through completely different pathways. And a study on vitamin a and e etc doesn't tell you much about other supplements. Just like how a study on does whether or not statins are associated with reduced mortality tells you little about whether or not ACE inhibitors are associated with reduced mortality. Also I don't think op meant primary source as in primary vs secondary sources but meant in the sense of "this doctor primarily uses Cochrane as his source for information"
qwerty456127 6y ago
Thank you for a very curious channel, I'm going to watch it all. Why does the doctor look so weird anyway? I mean his eyes - sort of a crazy gaze. Isn't he blind or something? Or is that an effect of a medication he takes?
- brian_herman 6y ago
  This is a video where he uses natural light and his eyes look normal. It is just bad lighting. https://www.youtube.com/watch?v=5kzaj-_vr1w https://www.youtube.com/watch?v=5kzaj-_vr1w
- redka 6y ago
  he seems to never blink
whycombagator 6y ago
Interesting, I've just used examine.com in the past. It's pretty reliable/decent and lower friction than a YT channel. Here is what Examine has on Glucosamine: https://examine.com/supplements/glucosamine/ https://examine.com/supplements/glucosamine/
deskamess 6y ago
Do you take Broccomax in addition to standard Glucosamine supplements? Or is Broccomax by itself sufficient?
hhas01 6y ago
Glucosamine supplementation looked decidedly unimpressive a decade ago and I don’t imagine anything has changed since. https://sciencebasedmedicine.org/?s=glucosamine https://sciencebasedmedicine.org/?s=glucosamine Still, I took a look at Dr Stanfield’s youtube channel (because nothing says “primary source” like a YT link): As a side note, here's all the supplements I currently take (affiliate links): WAKE UP: • Sulforaphane 8mg ( https://amzn.to/… ) • Niacin 50-500mg ( https://amzn.to/… ) - start low to help with flushing WORKOUT: • Creatine 2.5g before & after ( https://amzn.to/… ) BREAKFAST: • Vitamin K2 MK-7 90μg ( https://amzn.to/… ) • Vitamin D3 3,000 IU ( https://amzn.to/… ) • Omega-3 (DHA/EPA) two capsules ( https://amzn.to/… ) • Trans-Resveratrol 500mg ( https://amzn.to/… or https://cntr.click/… ) • Pterostilbene 150mg ( https://amzn.to/… ) • Collagen 10g ( https://amzn.to/… ) LUNCH: • Niacin 50-500mg ( https://amzn.to/… ) • Trimethylglycine (TMG) 750mg ( https://amzn.to/… or https://cntr.click/… ) NIGHT (one hour before sleeping): • Metformin 1 gram (only on non-workout days) • Melatonin 500mcg ( https://amzn.to/… ) • Magnesium Taurate 125mg ( https://amzn.to/… ) ONCE I can afford it (will take in the morning): • Nicotinamide Mononucleotide (NMN) 1 gram ( https://amzn.to/… or https://cntr.click/… ) Yeah, no. Oversold supplements for the neurotic well are a longtime health grift. 1PPM of actual science and medicine, diluted in 999,999PPM of ego-pampering, holy-rolling religion, and wishful anti-aging crap. BTW, here’s what your own Cochrane link says, which suggests you didn’t even bother to read it yourself: “The current evidence does not support the use of antioxidant supplements in the general population or in patients with various diseases.” IANAD, but I advise you apply some skepticism to that burn ASAP.

by evo_9 6y ago

hkt 6y ago

Is a Cochrane review really a primary source? They're meta-analysis, which I'd think of as secondary. In the case linked, the analysis seems pretty unequivocally to not support supplementing: "We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality, and so may higher doses of vitamin A. Antioxidant supplements need to be considered as medicinal products and should undergo sufficient evaluation before marketing." Did I miss something?

DiabloD3 6y ago
Vitamin E research also ends up being a bit YMMV: most commercially available Vitamin E is one form only, alpha tocopherol... except Vit E is 8 different forms: 4 tocopherols and 4 tocotrienols. The research that has been done so far basically indicates alpha tocopherol-only supplementation aligns identically with unspecified-Vitamin-E-is-bad research.
JamesBarney 6y ago
The op talks about sulforaphane but then links to an article about vitamin a and e(I don't know why) They're totally different chemicals that work through completely different pathways. And a study on vitamin a and e etc doesn't tell you much about other supplements. Just like how a study on does whether or not statins are associated with reduced mortality tells you little about whether or not ACE inhibitors are associated with reduced mortality. Also I don't think op meant primary source as in primary vs secondary sources but meant in the sense of "this doctor primarily uses Cochrane as his source for information"

qwerty456127 6y ago

Thank you for a very curious channel, I'm going to watch it all. Why does the doctor look so weird anyway? I mean his eyes - sort of a crazy gaze. Isn't he blind or something? Or is that an effect of a medication he takes?

brian_herman 6y ago
This is a video where he uses natural light and his eyes look normal. It is just bad lighting. https://www.youtube.com/watch?v=5kzaj-_vr1w https://www.youtube.com/watch?v=5kzaj-_vr1w
redka 6y ago
he seems to never blink

whycombagator 6y ago

Interesting, I've just used examine.com in the past. It's pretty reliable/decent and lower friction than a YT channel. Here is what Examine has on Glucosamine: https://examine.com/supplements/glucosamine/ https://examine.com/supplements/glucosamine/

deskamess 6y ago

Do you take Broccomax in addition to standard Glucosamine supplements? Or is Broccomax by itself sufficient?

hhas01 6y ago

Glucosamine supplementation looked decidedly unimpressive a decade ago and I don’t imagine anything has changed since. https://sciencebasedmedicine.org/?s=glucosamine https://sciencebasedmedicine.org/?s=glucosamine Still, I took a look at Dr Stanfield’s youtube channel (because nothing says “primary source” like a YT link): As a side note, here's all the supplements I currently take (affiliate links): WAKE UP: • Sulforaphane 8mg ( https://amzn.to/… ) • Niacin 50-500mg ( https://amzn.to/… ) - start low to help with flushing WORKOUT: • Creatine 2.5g before & after ( https://amzn.to/… ) BREAKFAST: • Vitamin K2 MK-7 90μg ( https://amzn.to/… ) • Vitamin D3 3,000 IU ( https://amzn.to/… ) • Omega-3 (DHA/EPA) two capsules ( https://amzn.to/… ) • Trans-Resveratrol 500mg ( https://amzn.to/… or https://cntr.click/… ) • Pterostilbene 150mg ( https://amzn.to/… ) • Collagen 10g ( https://amzn.to/… ) LUNCH: • Niacin 50-500mg ( https://amzn.to/… ) • Trimethylglycine (TMG) 750mg ( https://amzn.to/… or https://cntr.click/… ) NIGHT (one hour before sleeping): • Metformin 1 gram (only on non-workout days) • Melatonin 500mcg ( https://amzn.to/… ) • Magnesium Taurate 125mg ( https://amzn.to/… ) ONCE I can afford it (will take in the morning): • Nicotinamide Mononucleotide (NMN) 1 gram ( https://amzn.to/… or https://cntr.click/… ) Yeah, no. Oversold supplements for the neurotic well are a longtime health grift. 1PPM of actual science and medicine, diluted in 999,999PPM of ego-pampering, holy-rolling religion, and wishful anti-aging crap. BTW, here’s what your own Cochrane link says, which suggests you didn’t even bother to read it yourself: “The current evidence does not support the use of antioxidant supplements in the general population or in patients with various diseases.” IANAD, but I advise you apply some skepticism to that burn ASAP.