The Kinesis Advantage is the gold standard here. Have been using Kinesis keyboards for many years. Kinesis could of course have gone with an ortholinear layout

The Kinesis Advantage is the gold standard here. Have been using Kinesis keyboards for many years. Kinesis could of course have gone with an ortholinear layout but they didn't because the layout they chose much better maps to the actual geometry of the hand. Yes, it takes a few hours to learn to adapt, typically spread out over a couple days, but no that's not difficult and no it doesn't impact your ability to jump over to a normal keyboard. 100% stop to serious repetitive stress injury problems I had been experiencing with other keyboards, fully programmable layout, and a great high grade mechanical design that's lasted a decade or more without complaint.