This pre-registration strategy may work for very applied, translational, or clinical studies but it does not make sense to do this for basic science, where you

This pre-registration strategy may work for very applied, translational, or clinical studies but it does not make sense to do this for basic science, where you are constantly refining and redefining the scientific question. The reality is a lot of time spent by scientists is actually defining the problem properly (even after you think you’ve defined the problem properly), and preregistration studies would hinder the flexibility to adapt and change the direction given new understanding.