I think the "fit men" can be an issue when you are testing whether a drug works to reduce severity (treat) an infection. However, the question of whether the v

I think the "fit men" can be an issue when you are testing whether a drug works to reduce severity (treat) an infection. However, the question of whether the vaccine actually prevents infection should be relevant regardless of the level of fitness. You should probably only vaccinate half of them and when inevitably an unvaccinated person gets it, you should have very good data about protection two weeks later. This is all just a thought experiment of course (unless there are volunteers . . .)