4 ms·

That's because the clinical trials aren't studying hydroxychloroquine in conjunction with azithromycin, which is where the effect is noticable. They have to ac

by ColanR 6y ago

That's because the clinical trials aren't studying hydroxychloroquine in conjunction with azithromycin, which is where the effect is noticable. They have to actually study the thing that was indicated to work, if they're going to show it doesn't work.

fabian2k 6y ago
This is one trial looking at both, and it didn't find any effect: https://www.nejm.org/doi/full/10.1056/NEJMoa2019014?query=featured_home https://www.nejm.org/doi/full/10.1056/NEJMoa2019014?query=fe... I'm pretty sure there are more.
dragonwriter 6y ago
> That's because the clinical trials aren't studying hydroxychloroquine in conjunction with azithromycin, which is where the effect is noticable. Wrong. See, e.g., https://medcitynews.com/2020/07/hydroxychloroquine-flunks-phase-iii-trial-in-mild-to-moderate-covid-19/ https://medcitynews.com/2020/07/hydroxychloroquine-flunks-ph... “Results of the randomized, controlled, open-label Phase III trial, which took place at more than two dozen sites in Brazil, were published in the New England Journal of Medicine on Thursday. The study randomized 667 patients to receive hydroxychloroquine or the drug plus the antibiotic azithromycin on top of standard of care or standard of care alone. When patients were measured on the seven-point ordinal scale of improvement in disease, those in the two hydroxychloroquine groups showed no improvement compared with patients who received standard of care alone. Moreover, those receiving hydroxychloroquine more frequently experienced Qt prolongation and elevation of liver enzymes.”
- ColanR 6y ago
  The specific circumstances where the drugs are effective aren't being met. I didn't look up the details before. https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa093.. https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa093.... > Evidence about use of hydroxychloroquine alone, or of hydroxychloroquine+azithromycin in inpatients, is irrelevant concerning efficacy of the pair in early high-risk outpatient disease. Five studies, including two controlled clinical trials, have demonstrated significant major outpatient treatment efficacy.
  - irishjohnnie 6y ago
    ICYMI lots of issues with that study, https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa155/5873637 https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa155... https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa156/5873642 https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa156...
    - ColanR 6y ago
      I'm really sorry, I linked the wrong article. The quote in my comment is from the abstract of this [1] study. It's a meta-analysis by a professor of epidemiology at Yale. He also wrote an op-ed that ran in Newsweek. [2] [1] https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa093/5847586 https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa093... [2] https://www.newsweek.com/key-defeating-covid-19-already-exists-we-need-start-using-it-opinion-1519535 https://www.newsweek.com/key-defeating-covid-19-already-exis...

by ColanR 6y ago

fabian2k 6y ago

This is one trial looking at both, and it didn't find any effect: https://www.nejm.org/doi/full/10.1056/NEJMoa2019014?query=featured_home https://www.nejm.org/doi/full/10.1056/NEJMoa2019014?query=fe... I'm pretty sure there are more.

dragonwriter 6y ago

> That's because the clinical trials aren't studying hydroxychloroquine in conjunction with azithromycin, which is where the effect is noticable. Wrong. See, e.g., https://medcitynews.com/2020/07/hydroxychloroquine-flunks-phase-iii-trial-in-mild-to-moderate-covid-19/ https://medcitynews.com/2020/07/hydroxychloroquine-flunks-ph... “Results of the randomized, controlled, open-label Phase III trial, which took place at more than two dozen sites in Brazil, were published in the New England Journal of Medicine on Thursday. The study randomized 667 patients to receive hydroxychloroquine or the drug plus the antibiotic azithromycin on top of standard of care or standard of care alone. When patients were measured on the seven-point ordinal scale of improvement in disease, those in the two hydroxychloroquine groups showed no improvement compared with patients who received standard of care alone. Moreover, those receiving hydroxychloroquine more frequently experienced Qt prolongation and elevation of liver enzymes.”

ColanR 6y ago
The specific circumstances where the drugs are effective aren't being met. I didn't look up the details before. https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa093.. https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa093.... > Evidence about use of hydroxychloroquine alone, or of hydroxychloroquine+azithromycin in inpatients, is irrelevant concerning efficacy of the pair in early high-risk outpatient disease. Five studies, including two controlled clinical trials, have demonstrated significant major outpatient treatment efficacy.
- irishjohnnie 6y ago
  ICYMI lots of issues with that study, https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa155/5873637 https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa155... https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa156/5873642 https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa156...
  - ColanR 6y ago
    I'm really sorry, I linked the wrong article. The quote in my comment is from the abstract of this [1] study. It's a meta-analysis by a professor of epidemiology at Yale. He also wrote an op-ed that ran in Newsweek. [2] [1] https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa093/5847586 https://academic.oup.com/aje/article/doi/10.1093/aje/kwaa093... [2] https://www.newsweek.com/key-defeating-covid-19-already-exists-we-need-start-using-it-opinion-1519535 https://www.newsweek.com/key-defeating-covid-19-already-exis...