I would imagine the same persistent problem with human physiology -- which is the tendency towards homeostasis. Human body is remarkable in responsive to distu

I would imagine the same persistent problem with human physiology -- which is the tendency towards homeostasis. Human body is remarkable in responsive to disturbances in balance. You can generally throw things off a fair degree before the systems behind whatever you've thrown off adapt and scale down responses. Generally when you see things in the extreme in humans, somewhere in the line there's a malfunction in regulation that allowed that state to be reached (or chemical intervention, e.g. anabolic steroids, substance abuse, etc). Almost anything will work for a little, but the only thing that works forever are things that can become lifestyle factors. There are a handful of exceptions for "magic diet pills", but please for the love of god don't listen to what I'm about to say below as anything more than science: - Phentermine - [Rx but can outright buy it from "Medical Spas" pretty cheap (how is this legal?)] Stimulatory appetitete suppressant, effects are essentially amphetamine minus the dopaminergic activity (no high, sorry) ---- - Sibutramine - [Rx, Phentermine's little brother] ---- - 2,4-Dinitrophenol (DNP) - [Not legal for sale, but you can buy it online if you're determined] It's what's called a "mitochondrial uncoupler". It disrupts the Krebbs Cycle so that resynthesis of ATP from ADP becomes incredibly inefficient, and it expels the discarded energy as heat. This is the holy grail of fatloss. You can lose 1.0-1.5lbs of pure adipose tissue (not water/glycogen) per day. But the excess heat will cause you an incurable, agonizing death if you overdose. Also makes you hot all day, probably dangerous if you work in the heat.