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I don't believe the virus is known to behave like this to a very high probability. It's unknown but possible the virus behaves like dengue fever and gets worse

I don't believe the virus is known to behave like this to a very high probability. It's unknown but possible the virus behaves like dengue fever and gets worse the second time.

baxtr 6y ago
Well it’s a corona virus. We have four other corona viruses endemic in humans. So I think it’s ok to compare it to those others
nkohari 6y ago
At this point, if there was antibody-dependent enhancement, we would have seen at least one case of it clinically.
cesarb 6y ago
> It's unknown but possible the virus behaves like dengue fever and gets worse the second time. That's not how dengue works. There are four variants of the dengue virus, and it gets worse the second time only if it's a different variant. Quoting Wikipedia (https://en.wikipedia.org/wiki/Dengue_virus https://en.wikipedia.org/wiki/Dengue_virus): "Developing a vaccine against the disease is challenging. With four different serotypes of the virus that can cause the disease, the vaccine must immunize against all four types to be effective. Vaccination against only one serotype could possibly lead to severe dengue hemorrhagic shock when infected with another serotype due to antibody-dependent enhancement. When infected with dengue virus, the immune system produces cross-reactive antibodies that provide immunity to that particular serotype. However, these antibodies are incapable of neutralizing other serotypes upon reinfection and actually increase viral replication."
- manquer 6y ago
  Are there not three variants / strains of COVID 19 too ? . It is still too early now to say for sure , it is probable that second time may not come or be as severe but it is not certain
  - pmoriarty 6y ago
    There are variants of COVID-19, but there is no evidence that the variations are of any biological significance. There is no evidence that the variations change how infectious the virus is or how severe the illness is or how often people die from it or anything else.
    - manquer 6y ago
      Certainly I am not suggesting there is evidence, I am just saying it too early to dismiss the possibility . There is no concrete evidence saying it won't happen either. Seasonal Flu does mutate fast enough that any immunity is typically seasonal, so it unreasonable to consider the possibility of mutation

I don't believe the virus is known to behave like this to a very high probability. It's unknown but possible the virus behaves like dengue fever and gets worse the second time.

baxtr 6y ago

Well it’s a corona virus. We have four other corona viruses endemic in humans. So I think it’s ok to compare it to those others

nkohari 6y ago

At this point, if there was antibody-dependent enhancement, we would have seen at least one case of it clinically.

cesarb 6y ago

> It's unknown but possible the virus behaves like dengue fever and gets worse the second time. That's not how dengue works. There are four variants of the dengue virus, and it gets worse the second time only if it's a different variant. Quoting Wikipedia (https://en.wikipedia.org/wiki/Dengue_virus https://en.wikipedia.org/wiki/Dengue_virus): "Developing a vaccine against the disease is challenging. With four different serotypes of the virus that can cause the disease, the vaccine must immunize against all four types to be effective. Vaccination against only one serotype could possibly lead to severe dengue hemorrhagic shock when infected with another serotype due to antibody-dependent enhancement. When infected with dengue virus, the immune system produces cross-reactive antibodies that provide immunity to that particular serotype. However, these antibodies are incapable of neutralizing other serotypes upon reinfection and actually increase viral replication."

manquer 6y ago
Are there not three variants / strains of COVID 19 too ? . It is still too early now to say for sure , it is probable that second time may not come or be as severe but it is not certain
- pmoriarty 6y ago
  There are variants of COVID-19, but there is no evidence that the variations are of any biological significance. There is no evidence that the variations change how infectious the virus is or how severe the illness is or how often people die from it or anything else.
  - manquer 6y ago
    Certainly I am not suggesting there is evidence, I am just saying it too early to dismiss the possibility . There is no concrete evidence saying it won't happen either. Seasonal Flu does mutate fast enough that any immunity is typically seasonal, so it unreasonable to consider the possibility of mutation