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This reminds me of an excellent video on use of cheap and less sensitive tests on "This Week in Virology". https://youtu.be/kDj4Zyq3yOA https://youtu.be/kDj4Zy

by ilyagr 6y ago

This reminds me of an excellent video on use of cheap and less sensitive tests on "This Week in Virology". https://youtu.be/kDj4Zyq3yOA https://youtu.be/kDj4Zyq3yOA (Feel free to skip to around 6:35). Preprint: https://www.medrxiv.org/content/10.1101/2020.06.22.20136309v2 https://www.medrxiv.org/content/10.1101/2020.06.22.20136309v... Update: the colorado.edu article also links to this preprint when it discusses the "separate computer modelling study".

headmelted 6y ago
Upvoting for TWIV, which is my daily exercise podcast of choice until this thing is over (and probably afterwards too).
acqq 6y ago
The visual explanation of the ideas and concepts presented there, also mentioned in the later podcast: Medcram: “Coronavirus Pandemic Update 98: At Home COVID-19 Testing - A Possible Breakthrough” https://www.youtube.com/watch?v=h7Sv_pS8MgQ https://www.youtube.com/watch?v=h7Sv_pS8MgQ Also, regarding the Ct value, from: “Interpreting the COVID-19 Test Results: a Guide for Physiatrists” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268832/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268832/ In PCR tests “the diagnosis is made based on the threshold cycle (Ct) value. Ct is defined as the cycle number when the sample fluorescence exceeds a chosen threshold above the calculated background fluorescence.5 In other words, the lower the Ct value of a specific gene, the more the gene exists in the sample. However, the problem with a Ct-based diagnosis is that there is no absolute or constant Ct cut-off value, and Ct cut-off values are different for each diagnostic reagent even for the same gene.”
aquadrop 6y ago
Yep, this was an eye opening video, showing how current mindset for virus test accuracy is wrong. If early on we channeled even small portion of all the trillions used to help with covid negative effects, world would be much better off now.

by ilyagr 6y ago

headmelted 6y ago

Upvoting for TWIV, which is my daily exercise podcast of choice until this thing is over (and probably afterwards too).

acqq 6y ago

The visual explanation of the ideas and concepts presented there, also mentioned in the later podcast: Medcram: “Coronavirus Pandemic Update 98: At Home COVID-19 Testing - A Possible Breakthrough” https://www.youtube.com/watch?v=h7Sv_pS8MgQ https://www.youtube.com/watch?v=h7Sv_pS8MgQ Also, regarding the Ct value, from: “Interpreting the COVID-19 Test Results: a Guide for Physiatrists” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268832/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268832/ In PCR tests “the diagnosis is made based on the threshold cycle (Ct) value. Ct is defined as the cycle number when the sample fluorescence exceeds a chosen threshold above the calculated background fluorescence.5 In other words, the lower the Ct value of a specific gene, the more the gene exists in the sample. However, the problem with a Ct-based diagnosis is that there is no absolute or constant Ct cut-off value, and Ct cut-off values are different for each diagnostic reagent even for the same gene.”

aquadrop 6y ago

Yep, this was an eye opening video, showing how current mindset for virus test accuracy is wrong. If early on we channeled even small portion of all the trillions used to help with covid negative effects, world would be much better off now.