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Good T-cell response has historically come from replication competent virus (live virus vaccine) because the process of replicating their genetic material and p

Good T-cell response has historically come from replication competent virus (live virus vaccine) because the process of replicating their genetic material and producing proteins triggers many of the T-cell responses. Inactivated virus vaccines or protein sub-unit vaccines require adjuvants to trigger these mechanisms and have never given protection as good as live virus. mRNA and viral vector (which are the leading approaches right now) are very new and try to produce the effect of live virus vaccine without having to first find an attenuated, stable vaccine strain. They do this by using either another virus or a lipid shell to inject genetic material into cells which starts the cells producing proteins. I would expect both the Moderna and the Oxford vaccine to give some T-cell immunity as well as antibodies.

bdonlan 6y ago
Moderna (mRNA), Pfizer (mRNA) and Oxford (viral vector) have all reported T-cell activity. Sources: * https://blogs.sciencemag.org/pipeline/archives/2020/07/15/modernas-phase-i-data https://blogs.sciencemag.org/pipeline/archives/2020/07/15/mo... * https://blogs.sciencemag.org/pipeline/archives/2020/07/20/more-pfizer-phase-i-results-antibodies-viral-mutations-and-t-cells https://blogs.sciencemag.org/pipeline/archives/2020/07/20/mo... * https://blogs.sciencemag.org/pipeline/archives/2020/07/20/new-data-on-the-oxford-az-vaccine https://blogs.sciencemag.org/pipeline/archives/2020/07/20/ne... (these blogs link the actual preprint primary source as well)