14 ms·

I don't think it is clear at this point that there are unexpected antibody titer drops in comparison to other viruses, Florian Krammer's work looks solid to me:

• baxtr 6y ago
  It’s at least not perfectly clear yet. I know some people who tested PCR positive and had negative AB test outcomes. Kramer writes in his pre-print that you’ve linked: >Of note, our observations are in contrast to a recent report by Long et al. that found waning titers 8 weeks post 138 virus infection as compared to acute responses (19). Especially in asymptomatic cases, antibody 139 responses disappeared after 8 weeks in 40% of individuals in the Long et al. study. However, the 140 antibodies measured in their paper were targeting the NP plus a single linear spike epitope. Much 141 more in agreement with our data, the same paper also reports relatively stable (slightly declining) 142 neutralizing antibody titers. The stability of the antibody response over time might therefore also 143 depend on the target antigen. The titers we measure here do correlate with neutralization as 144 discussed above.