There are newer methods that use antibodies to enrich for methylated dna prior to sequencing [1]. The method increases sensitivity as the majority of plasma cfD

There are newer methods that use antibodies to enrich for methylated dna prior to sequencing [1]. The method increases sensitivity as the majority of plasma cfDNA is unmethylated and hematopoietic in origin. [1] https://www.nature.com/articles/s41586-018-0703-0 https://www.nature.com/articles/s41586-018-0703-0