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As someone very pro-vaccine, what are the risks of doing this? Is the worst case scenario you get the vaccine and not a placebo and it does nothing? Are there r

As someone very pro-vaccine, what are the risks of doing this? Is the worst case scenario you get the vaccine and not a placebo and it does nothing? Are there real health risks to doing this?

SaltyLemonZest 6y ago
Vaccines in general have the potential to produce what's known as "antibody-dependent enhancement", where the disease will be even worse for you than if you didn't have a vaccine. Researchers don't think this is a factor for coronavirus vaccines, but if they're wrong it wouldn't have been detected in phase 1 and 2 studies.
apsec112 6y ago
The vaccines could have side effects - they have all been mild so far, but some could (eg.) cause a serious reaction 0.1% of the time.
- devalgo 6y ago
  Is there a standard set of potential side effects? Lets say some of these potential vaccines are effective at producing an immune response enough to provide protection from Covid infection, is there a level of side effects that would cause a vaccine to fail clinical trials?
KerrickStaley 6y ago
The podcast Science Vs. described one patient who received an experimental vaccine and had severe (but not life-threatening) fever-like side effects including fainting, nausea/vomiting, chills, and lethargy/weakness: > When I woke up, I woke up this was at noon the next day, I had to get up to go to the bathroom, on the way there I felt really nauseous and actually ended up throwing up in the bathroom and then I just collapsed. I remember waking up on the floor, though, and looking up and seeing the underside of the kitchen table, which was a very confusing sight So by taking an experimental vaccine you're risking these sorts of side effects. In this particular study there were 45 participants and 3 had severe side effects of this nature. Full transcript: https://docs.google.com/document/d/e/2PACX-1vQ78hrs4ldf6abmAwrHfrQwvCnfK2cJG5ARVLnwZs2zob1F1s_oKzZO7zAPKUSjuSKL5frfo3RLHipU/pub https://docs.google.com/document/d/e/2PACX-1vQ78hrs4ldf6abmA... Episode: https://gimletmedia.com/shows/science-vs/dvh28wk/coronavirus-dude-wheres-my-vaccine https://gimletmedia.com/shows/science-vs/dvh28wk/coronavirus...
- belltaco 6y ago
  The Google doc is really hard to skim, did that happen in Phase 3? Severe side effects are more common in Phase 1 trial, this is phase 3.
  - KerrickStaley 6y ago
    The podcast did not indicate what phase of trial this was.

As someone very pro-vaccine, what are the risks of doing this? Is the worst case scenario you get the vaccine and not a placebo and it does nothing? Are there real health risks to doing this?

SaltyLemonZest 6y ago

Vaccines in general have the potential to produce what's known as "antibody-dependent enhancement", where the disease will be even worse for you than if you didn't have a vaccine. Researchers don't think this is a factor for coronavirus vaccines, but if they're wrong it wouldn't have been detected in phase 1 and 2 studies.

apsec112 6y ago

The vaccines could have side effects - they have all been mild so far, but some could (eg.) cause a serious reaction 0.1% of the time.

devalgo 6y ago
Is there a standard set of potential side effects? Lets say some of these potential vaccines are effective at producing an immune response enough to provide protection from Covid infection, is there a level of side effects that would cause a vaccine to fail clinical trials?

KerrickStaley 6y ago

The podcast Science Vs. described one patient who received an experimental vaccine and had severe (but not life-threatening) fever-like side effects including fainting, nausea/vomiting, chills, and lethargy/weakness: > When I woke up, I woke up this was at noon the next day, I had to get up to go to the bathroom, on the way there I felt really nauseous and actually ended up throwing up in the bathroom and then I just collapsed. I remember waking up on the floor, though, and looking up and seeing the underside of the kitchen table, which was a very confusing sight So by taking an experimental vaccine you're risking these sorts of side effects. In this particular study there were 45 participants and 3 had severe side effects of this nature. Full transcript: https://docs.google.com/document/d/e/2PACX-1vQ78hrs4ldf6abmAwrHfrQwvCnfK2cJG5ARVLnwZs2zob1F1s_oKzZO7zAPKUSjuSKL5frfo3RLHipU/pub https://docs.google.com/document/d/e/2PACX-1vQ78hrs4ldf6abmA... Episode: https://gimletmedia.com/shows/science-vs/dvh28wk/coronavirus-dude-wheres-my-vaccine https://gimletmedia.com/shows/science-vs/dvh28wk/coronavirus...

belltaco 6y ago
The Google doc is really hard to skim, did that happen in Phase 3? Severe side effects are more common in Phase 1 trial, this is phase 3.
- KerrickStaley 6y ago
  The podcast did not indicate what phase of trial this was.