4 ms·
I was curious about how administering a cytokine could improve survival, especially since there's evidence of cytokine storm in severe cases. A cursory look on
by nicktelford 6y ago
I was curious about how administering a cytokine could improve survival, especially since there's evidence of cytokine storm in severe cases.
A cursory look on wikipedia[1]:
> Since there is evidence that insufficient production of interferon beta-1a in lung cells in older people can lead to their increased susceptibility to respiratory viral infections such as SARS-CoV-2 and MERS-CoV, replenishing the deficiency of this interferon can protect against the dire effects of these diseases. Company Synairgen began clinical tests of SNG001, a special inhalation formulation of interferon beta-1a in patients with COVID-19
So it sounds like this treatment (assuming it is effective) would only be especially effective in older people (or younger people with some kind of Interferon beta-1-a deficiency I guess), and only if administered relatively early in the course of the disease - i.e. before development of pneumonia.
1: https://en.wikipedia.org/wiki/Interferon_beta-1a#Clinical_trials https://en.wikipedia.org/wiki/Interferon_beta-1a#Clinical_tr...
- cytowhatever 6y agoCytokine just means ‘cell signalling molecule’. The word doesn’t tell us anything, or anything much at all, about what those cell signalling molecules do, where they came from, nor what their target / recipients are. Source: studied a bit of anatomy and physiology & pathophysiology along the way. From Wikipedia: The word comes from Greek: cyto, from Greek "κύτος" kytos "cavity, cell" + kines, from Greek "κίνησις" kinēsis "movement". https://en.wikipedia.org/wiki/Cytokine https://en.wikipedia.org/wiki/Cytokine