3 ms·

Rubbish HN article title. The Abstract and Intro in the article do not mention the word iron at all. Later on we get: "Mendelian randomisation of iron traits"

Rubbish HN article title. The Abstract and Intro in the article do not mention the word iron at all. Later on we get: "Mendelian randomisation of iron traits" and the HN title looks very suspect. The sort of cobblers a supplement pusher might write.

1996 6y ago
Rubbish comment. The paper studies many things and found iron metabolism is a common factor for aging. "Haem synthesis declines with age and its deficiency leads to iron accumulation, oxidative stress, and mitochondrial dysfunction. In turn, iron accumulation helps pathogens to sustain an infection, which is in line with the known increase in infection susceptibility with age. In the brain, abnormal iron homeostasis is commonly seen in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease and multiple sclerosis" Also FYI in the title "Multivariate genomic scan implicates novel loci and haem metabolism in human ageing", haem implies iron.
bookofjoe 6y ago
>Haem Definition and Examples - Biology Online Dictionary >What does haem mean in biology? haem. 1. (Science: biochemistry) compounds of iron complexed in a porphyrin (tetrapyrrole) ring that differ in side chain composition.
pizza 6y ago
From the abstract: "we identify a pathway worthy of further study: haem metabolism."
DangerousPie 6y ago
haem = ~ iron
rch 6y ago
I submitted it yesterday with the original title and it didn't get any attention, possibly because it's a little dense. I'm happy to see the article on the front page now, from a different submitter, as the topic is generally of interest here.
ImaCake 6y ago
Mendelian randomisation is somewhat of a gold standard for analysing this kind of data. It is a technique to try and establish causal relationships between gene variations and phenotype. Definitely not the kind of crap pushed by a "supplement pusher".

1996 6y ago

Rubbish comment. The paper studies many things and found iron metabolism is a common factor for aging. "Haem synthesis declines with age and its deficiency leads to iron accumulation, oxidative stress, and mitochondrial dysfunction. In turn, iron accumulation helps pathogens to sustain an infection, which is in line with the known increase in infection susceptibility with age. In the brain, abnormal iron homeostasis is commonly seen in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease and multiple sclerosis" Also FYI in the title "Multivariate genomic scan implicates novel loci and haem metabolism in human ageing", haem implies iron.

bookofjoe 6y ago

>Haem Definition and Examples - Biology Online Dictionary >What does haem mean in biology? haem. 1. (Science: biochemistry) compounds of iron complexed in a porphyrin (tetrapyrrole) ring that differ in side chain composition.

pizza 6y ago

From the abstract: "we identify a pathway worthy of further study: haem metabolism."

DangerousPie 6y ago

haem = ~ iron

rch 6y ago

I submitted it yesterday with the original title and it didn't get any attention, possibly because it's a little dense. I'm happy to see the article on the front page now, from a different submitter, as the topic is generally of interest here.

ImaCake 6y ago

Mendelian randomisation is somewhat of a gold standard for analysing this kind of data. It is a technique to try and establish causal relationships between gene variations and phenotype. Definitely not the kind of crap pushed by a "supplement pusher".