Too late to the thread but I will give it a shot. First of all, the Blue Brain Project (equivalent of the US Human Brain Project) has been widely criticised wi

Too late to the thread but I will give it a shot. First of all, the Blue Brain Project (equivalent of the US Human Brain Project) has been widely criticised within the neuroscience community for its failures to invest the funding appropriately [0,1] as well as failing to produce their exaggerated claims of "brain on a computer", even 3 years after this article was published. Secondly, it is insanely hard to even map in all the connections between neurons with their thousands of synapses. Imagine one neuron connects to another 1000 neurons and a cubic millimeter of mouse cortex contains about 9×10^4 neurons. Even 1mm3 of cortex hasn't been mapped yet for a rodent (mouse/rat) brain. Mapping the whole rodent brain will easily take another decade [2]. Thirdly, even when you have mapped the complete brain, inferring states of consiousness from it is a far fetched hypothesis and most neuroscients don't even dare to go there because it is so absurd to talk about it from incomplete simulation models. Given the complexity of wiring of neurons and the sheer amount of specific nature of this wiring, building simulation models assumes that the connections between neurons are totally random which is an age old view which computational neuroscientists are now starting to accept (except the BBP, for now). Contrary to the BBP simulation models, this [3] model actually pays attention to the observed wiring from past experiments and is the closest to anything "realistic" but of course with several caveats. [0] https://www.scientificamerican.com/article/why-the-human-brain-project-went-wrong-and-how-to-fix-it/ https://www.scientificamerican.com/article/why-the-human-bra... [1] https://www.theatlantic.com/science/archive/2019/07/ten-years-human-brain-project-simulation-markram-ted-talk/594493/ https://www.theatlantic.com/science/archive/2019/07/ten-year... [2] https://pubmed.ncbi.nlm.nih.gov/31055238/ https://pubmed.ncbi.nlm.nih.gov/31055238/ [3] https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006535#abstract1 https://journals.plos.org/ploscompbiol/article?id=10.1371/jo...