4 ms·

I actually believe this to be the case. From what I have read researchers often do something called gain of function research. In this research they add genetic

by stx 6y ago

I actually believe this to be the case. From what I have read researchers often do something called gain of function research. In this research they add genetic features to viruses that could make it more infective. This is done, at least in part, to help learn how to protect society from such a virus if it were to evolve naturally. I thought I heard somewhere that one of the functions coronavirus has that its closest known relatives do not have just happens to be something that virologists frequently add. All this leads me to believe it was created in a lab. Likely for altruistic purposes but still. When this escaped whoever knew that it was from a lab should have disclosed it ASAP to help the world prepare. I have no experience in virology so don't trust me.

sudosysgen 6y ago
The thing I just don't understand is why gain research would take the effort of making the virus much less deadly. This virus is around ten times less deadly that SARS, wouldn't gain research at least maintain virulence?
- WrtCdEvrydy 6y ago
  Depends, what if you had a virus that caused the same antiviral response as SARS on the immune system but had no deaths (couldn't cause death)?
- nickfromseattle 6y ago
  You switch from death rate or R0, so it's not clear which variable you are referring to. COVID-19 may be less deadly, but it has killed more people than SARS. So it does appear to be a 'better' virus.
- Confusion 6y ago
  One way of discovering what increases property X is testing that some change decreases property X. Another way of discovering what increases property X is testing that some change indeed increases property X, while also discovering it decreases property Y. While attempting to increase both X and Y, they made an intermediate with increased X and decreased Y. Perhaps it seemed a promising starting point to also increase Y. I don't get the surprise. This is all par for the course in research.
esalman 6y ago
I do not have experience in virology either but what you heard is correct. Researchers do work on creating new strains of viruses, with the goal being development of vaccines before epidemics start.

by stx 6y ago

sudosysgen 6y ago

The thing I just don't understand is why gain research would take the effort of making the virus much less deadly. This virus is around ten times less deadly that SARS, wouldn't gain research at least maintain virulence?

WrtCdEvrydy 6y ago
Depends, what if you had a virus that caused the same antiviral response as SARS on the immune system but had no deaths (couldn't cause death)?
nickfromseattle 6y ago
You switch from death rate or R0, so it's not clear which variable you are referring to. COVID-19 may be less deadly, but it has killed more people than SARS. So it does appear to be a 'better' virus.
Confusion 6y ago
One way of discovering what increases property X is testing that some change decreases property X. Another way of discovering what increases property X is testing that some change indeed increases property X, while also discovering it decreases property Y. While attempting to increase both X and Y, they made an intermediate with increased X and decreased Y. Perhaps it seemed a promising starting point to also increase Y. I don't get the surprise. This is all par for the course in research.

esalman 6y ago

I do not have experience in virology either but what you heard is correct. Researchers do work on creating new strains of viruses, with the goal being development of vaccines before epidemics start.