3 ms·
I had no idea there was more to the page because of the weird scrolling on the site, so I missed the glycan (sugar) stuff, which is my bread and butter. I thin
by hirenj 6y ago
I had no idea there was more to the page because of the weird scrolling on the site, so I missed the glycan (sugar) stuff, which is my bread and butter.
I think the consensus is that there is not likely any shielding going on with the glycans (like what you would find with HIV), but there are glycans that stabilise the ACE2 binding part. Also, people have found glycans on a protein cleavage region, which I would expect could impart resistance to cleavage (a predictor I wrote from a few years back correctly predicted those sites).
- aeternum 6y agoSeems like this would be much better as a video. It probably took a tons of effort to put this into a webpage and it was quite buggy and unintuitive.