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What is the error rate of the immune system response currently used, compared to actual immune response? If it is small, then the value of infecting humans dire
by simiones 6y ago
What is the error rate of the immune system response currently used, compared to actual immune response? If it is small, then the value of infecting humans directly goes way down. Further, what is the probability that the control group and the vaccine groups will not be exposed naturally and accidentally to Covid19 during the Phase II, Phase III studies? If they are likely to be accidentally exposed, then purposefully exposing them has even less value. Given the current infection rates in the US, this likelihood seems pretty good.
The 277,145 number is meaningless. The vaccine was not known to help in any way 2 months ago. For all we knew at the time, if we had started giving this to people on mass 2 months ago, we would have had 300k deaths from the vaccine by now.
Then, the vaccine is not yet known to be effective. We only have proof that it is safe, but we don't have rigorous control studies showing that it is effective yet (we need the Phase II & III trials for that). Before that, there is only a "hunch" that it will help at all, so taking death numbers for the next few months is also going to be meaningless.
Finally, your "even if the data sped up the research by only one day" calculation is pure sophism. Why not assume that the data could slow down the research? What if one of the patients dies because of complications after being infected, and that affects team morale, slowing down the research? What if one of the researchers accidentally gets sick themselves because of improper handling of the live virus, again slowing down the research?
The final point is: we are already rushing this. There are good reasons we have stopped testing drugs on volunteers, we have a horrible history behind us of the effects, often without much better results (and often much worse results) than current methods. There methods we have for estimating actual immunity based on immune system response have been studied for some time and are considered good. Putting people's lives in danger is needless complication, more likely to slow everything down than to speed it up.