3 ms·

I'm very nervous about the safety of any vaccine based on a complete spike protein S1 Receptor Binding Domain (RBD), What make one more worrying than the other

I'm very nervous about the safety of any vaccine based on a complete spike protein S1 Receptor Binding Domain (RBD), What make one more worrying than the other? I have not the expertise to make such inferences

whymauri 6y ago
I'm guessing they have target specificity concerns. I'm no spike protein expert, but the concern would be that spike-targeting ligands can bind to other off-target sites, leading to unexpected and unwanted side effects. What they think these side effects might be, I have no idea.
- sjg007 6y ago
  Vs targeting receptors?
- AprilArcus 6y ago
  There are a few possibilities in my mind. * T Cell mediated inflammatory cascade (Cytokine storm) caused by off-target cross-reactivity with IL-11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092895/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092895/ * Autoimmune responses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809466/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809466/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/ * Antibody-Dependent Enhancement of viral entry: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018502/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018502/