4 ms·

I'm very nervous about the safety of any vaccine based on a complete spike protein, and worried that if one is rushed to market it will have such disastrous sid

I'm very nervous about the safety of any vaccine based on a complete spike protein, and worried that if one is rushed to market it will have such disastrous side effects that it will be an antivaxxer talking point for the next century. The only vaccines I'm really excited about are the ones based on S1 Receptor Binding Domain (RBD), none of which are yet in stage 1.

addictedcs 6y ago
Very thoughtful point. I was concerned about it as well. Rushing a half-backed vaccine that has serious side-effects will fuel antivaxxers for decades.
- hannob 6y ago
  Frankly I don't buy that. There has actually been something like this during the swine flu pandemic. There was a vaccine that is believed to have caused some cases of narcolepsy. This was a real, bad sideeffect with a vaccine that was rushed to market. Surprisingly this isn't a big talking point in antivaccine circles. Yeah you'll hear about it sometimes, but compare it to the number of times you hear "somethingsomething MMR aluminium autism" which is all debunked bullshit - you'll hear that far more often. What I want to say is: Antivaccine people largely don't care about real issues with vaccines. They're happy with their pseudoscientific nonsense, that's good enough for them to reject every vaccine ever made.
  - objektif 6y ago
    I also happen to agree with you it is very unlikely that more people will become anti-vaxer just because covid vaccine was not effective.
- WrtCdEvrydy 6y ago
  Death of their kids has fueled them for centuries and they don't see that concerned about it.
The_rationalist 6y ago
I'm very nervous about the safety of any vaccine based on a complete spike protein S1 Receptor Binding Domain (RBD), What make one more worrying than the other? I have not the expertise to make such inferences
- whymauri 6y ago
  I'm guessing they have target specificity concerns. I'm no spike protein expert, but the concern would be that spike-targeting ligands can bind to other off-target sites, leading to unexpected and unwanted side effects. What they think these side effects might be, I have no idea.
  - sjg007 6y ago
    Vs targeting receptors?
  - AprilArcus 6y ago
    There are a few possibilities in my mind. * T Cell mediated inflammatory cascade (Cytokine storm) caused by off-target cross-reactivity with IL-11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092895/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092895/ * Autoimmune responses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809466/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809466/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/ * Antibody-Dependent Enhancement of viral entry: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018502/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018502/

addictedcs 6y ago

Very thoughtful point. I was concerned about it as well. Rushing a half-backed vaccine that has serious side-effects will fuel antivaxxers for decades.

hannob 6y ago
Frankly I don't buy that. There has actually been something like this during the swine flu pandemic. There was a vaccine that is believed to have caused some cases of narcolepsy. This was a real, bad sideeffect with a vaccine that was rushed to market. Surprisingly this isn't a big talking point in antivaccine circles. Yeah you'll hear about it sometimes, but compare it to the number of times you hear "somethingsomething MMR aluminium autism" which is all debunked bullshit - you'll hear that far more often. What I want to say is: Antivaccine people largely don't care about real issues with vaccines. They're happy with their pseudoscientific nonsense, that's good enough for them to reject every vaccine ever made.
- objektif 6y ago
  I also happen to agree with you it is very unlikely that more people will become anti-vaxer just because covid vaccine was not effective.
WrtCdEvrydy 6y ago
Death of their kids has fueled them for centuries and they don't see that concerned about it.

The_rationalist 6y ago

I'm very nervous about the safety of any vaccine based on a complete spike protein S1 Receptor Binding Domain (RBD), What make one more worrying than the other? I have not the expertise to make such inferences

whymauri 6y ago
I'm guessing they have target specificity concerns. I'm no spike protein expert, but the concern would be that spike-targeting ligands can bind to other off-target sites, leading to unexpected and unwanted side effects. What they think these side effects might be, I have no idea.
- sjg007 6y ago
  Vs targeting receptors?
- AprilArcus 6y ago
  There are a few possibilities in my mind. * T Cell mediated inflammatory cascade (Cytokine storm) caused by off-target cross-reactivity with IL-11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092895/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092895/ * Autoimmune responses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809466/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809466/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/ * Antibody-Dependent Enhancement of viral entry: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018502/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018502/