8 ms·

There's a host of rare diseases that originate from mtDNA mutations that this could have applications in. I know the tech/Silicon Valley crowd tends to love ant

There's a host of rare diseases that originate from mtDNA mutations that this could have applications in. I know the tech/Silicon Valley crowd tends to love anti-aging stuff as well, so for all y'all into life extension stuff, this should interest you as well because of mitochondria's hypothesized role in aging[0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779179/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779179/

phkahler 6y ago
That link looks like a good read. Long so I bookmarked for later.
- pointer_pointer 6y ago
  Please tell us more. What did you do next ? Thank you for blogging here.
at_a_remove 6y ago
Yes, I have one of them, so I will be watching this. Probably entirely too long to market for it to be of help to me but it is nice to know that it will be coming for others.
monocasa 6y ago
One of my coworker's children died of a mtDNA mutation he was born with at three years old. My coworker never really got completely over the loss. They knew pretty early on what the prognosis was, but spent those three years giving the kid the best life they could. I'm super excited to see work that might give this whole class of children a long life at some point in the future. Just a few years ago (pre CRISPR), it was just accepted as a shitty thing we couldn't do anything about.
cachestash 6y ago
I have been taking a high grade CoQ10 supplement. CoQ10 is the primary antioxidant the human cell provides to protect and support mitochondria. It helps generate ATP within the mitochondria, the main energy driver we have. CoQ10 is ubiquitous and produce within the body, however after the age of 20 levels start to drop, so it makes sense to consider supplements to top levels up if you're north of 30. I love the stuff myself. I went from a tired feeling 45 year old with brain fog, to having a lot more energy and a mind keen to engage all day with whatever I have going on at work https://examine.com/supplements/coenzyme-q10/#effect-matrix https://examine.com/supplements/coenzyme-q10/#effect-matrix
- mdszy 6y ago
  Nice supplement spam, bud.
- evo_9 6y ago
  You should watch this excellent video by Dr Stanfield (actually, entire channel is excellent) in which he goes into Cochrane Medical Reviews among other research channels to dig into the science around all this stuff. This video is his analysis of CoQ10: https://www.youtube.com/watch?v=I9UYRWLpXz8 https://www.youtube.com/watch?v=I9UYRWLpXz8 Dr Stanfield recommends sulforaphane over C0Q10 and the science/medical evidence he presents is compelling; he has a few videos specifically on sulforaphane as well. I would highly recommend anyone that is doubtful of vitamins and suppliments, particularly relating to aging/longevity - really give this YouTube channel a thorough review. It's hard to discount Cochrane Reviewed[0] backed data. [0] https://www.cochranelibrary.com/ https://www.cochranelibrary.com/
  - pstuart 6y ago
    Sulforaphane? Queue up Dr. Rhonda Patrick! https://www.foundmyfitness.com/episodes/sulforaphane https://www.foundmyfitness.com/episodes/sulforaphane
    - dharma1 6y ago
      Those youtube comments are gold. "It really is hard to belive she's in her 80's! Amazing." "Do not listen to Rhonda... she's a shill for big broccoli!!"
- ve55 6y ago
  For those interested in this substance, it is worth first noting that it is present in many common foods in notable quantities: https://en.wikipedia.org/wiki/Coq10#Dietary_concentrations https://en.wikipedia.org/wiki/Coq10#Dietary_concentrations
- pengaru 6y ago
  How did you disambiguate these claimed CoQ10 effects from the results of taping your mouth shut at night? "Not only did it fix my apnoea [sic] and huge lack of energy during the day" https://news.ycombinator.com/item?id=23432440 https://news.ycombinator.com/item?id=23432440

phkahler 6y ago

That link looks like a good read. Long so I bookmarked for later.

pointer_pointer 6y ago
Please tell us more. What did you do next ? Thank you for blogging here.

at_a_remove 6y ago

Yes, I have one of them, so I will be watching this. Probably entirely too long to market for it to be of help to me but it is nice to know that it will be coming for others.

monocasa 6y ago

One of my coworker's children died of a mtDNA mutation he was born with at three years old. My coworker never really got completely over the loss. They knew pretty early on what the prognosis was, but spent those three years giving the kid the best life they could. I'm super excited to see work that might give this whole class of children a long life at some point in the future. Just a few years ago (pre CRISPR), it was just accepted as a shitty thing we couldn't do anything about.

cachestash 6y ago

I have been taking a high grade CoQ10 supplement. CoQ10 is the primary antioxidant the human cell provides to protect and support mitochondria. It helps generate ATP within the mitochondria, the main energy driver we have. CoQ10 is ubiquitous and produce within the body, however after the age of 20 levels start to drop, so it makes sense to consider supplements to top levels up if you're north of 30. I love the stuff myself. I went from a tired feeling 45 year old with brain fog, to having a lot more energy and a mind keen to engage all day with whatever I have going on at work https://examine.com/supplements/coenzyme-q10/#effect-matrix https://examine.com/supplements/coenzyme-q10/#effect-matrix

mdszy 6y ago
Nice supplement spam, bud.
evo_9 6y ago
You should watch this excellent video by Dr Stanfield (actually, entire channel is excellent) in which he goes into Cochrane Medical Reviews among other research channels to dig into the science around all this stuff. This video is his analysis of CoQ10: https://www.youtube.com/watch?v=I9UYRWLpXz8 https://www.youtube.com/watch?v=I9UYRWLpXz8 Dr Stanfield recommends sulforaphane over C0Q10 and the science/medical evidence he presents is compelling; he has a few videos specifically on sulforaphane as well. I would highly recommend anyone that is doubtful of vitamins and suppliments, particularly relating to aging/longevity - really give this YouTube channel a thorough review. It's hard to discount Cochrane Reviewed[0] backed data. [0] https://www.cochranelibrary.com/ https://www.cochranelibrary.com/
- pstuart 6y ago
  Sulforaphane? Queue up Dr. Rhonda Patrick! https://www.foundmyfitness.com/episodes/sulforaphane https://www.foundmyfitness.com/episodes/sulforaphane
  - dharma1 6y ago
    Those youtube comments are gold. "It really is hard to belive she's in her 80's! Amazing." "Do not listen to Rhonda... she's a shill for big broccoli!!"
ve55 6y ago
For those interested in this substance, it is worth first noting that it is present in many common foods in notable quantities: https://en.wikipedia.org/wiki/Coq10#Dietary_concentrations https://en.wikipedia.org/wiki/Coq10#Dietary_concentrations
pengaru 6y ago
How did you disambiguate these claimed CoQ10 effects from the results of taping your mouth shut at night? "Not only did it fix my apnoea [sic] and huge lack of energy during the day" https://news.ycombinator.com/item?id=23432440 https://news.ycombinator.com/item?id=23432440