4 ms·

The Thought Emporium

20 points by apsec112 6y ago

SilasHaslam 6y ago
Found this one: "Developing a Permanent Treatment for Lactose Intolerance Using Gene Therapy" Seems very promising. Recently, I discovered that lactase derived from Kluyveromyces lactis is effective for me, whereas lactase derived from Aspergillus oryzae seems to have little to no effect. The latter is used in mose lactase supplements
- dmart 6y ago
  This is interesting. Do you know which brands are derived from each source? I wasn't able to find much information online.
  - SilasHaslam 6y ago
    Source info is usually tucked away in fine print, or on the manufacturer's FAQ page, if at all. "Lactose-free" dairy products (milks and yogurts) and OTC supplements in pill form, as far as I know, use lactase derived from A. oryzae. Commercial dairy supply companies sell K. lactis in bulk. I've found one brand on Amazon (SeekingHealth) that's made with K. lactis derive lactose. Maybe they re-package the commercial size product? I've thought about buying a gallon for $1200, but that would probably last me more than a lifetime. Lactase comes from different sources and has different properties [0]. K. lactis has a neutral optimal pH, so it's better for processing dairy prior to consumption; A. oryzae has a lower optimal pH and higher heat tolerance, so it's more suitable for OTC supplements. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429307/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429307/
bil7 6y ago
this guy has some really great youtube videos, particularly enjoyed the series on building a camera to "see wifi"
- foobiekr 6y ago
  Agreed. I really like them... Though ... his live streams are pretty revealing. I recommend watching a few of them, as it will probably change the way you view his other content, both in the positive sense and in the negative.
  - shawa_a_a 6y ago
    I’ve only watched his WiFi video, as well as his Lactose Intolerance gene therapy and felt he cane across quite positively. Are you alluding to specific negative behaviours he exhibits on stream that are edited from his videos?
    - foobiekr 6y ago
      I suggest watching a few and just drawing your own conclusions. I'm not being coy, I just think that the conclusions I drew may be pretty unfairly negative and I don't necessarily want to bias you.
freezing_coffee 6y ago
Have been a patron for some time, and discovered his channel with his lactose gene therapy video - to which he recently posted an update: https://www.youtube.com/watch?v=aoczYXJeMY4 https://www.youtube.com/watch?v=aoczYXJeMY4 . Great addition to scientific youtube.

20 points by apsec112 6y ago

Found this one: "Developing a Permanent Treatment for Lactose Intolerance Using Gene Therapy" Seems very promising. Recently, I discovered that lactase derived from Kluyveromyces lactis is effective for me, whereas lactase derived from Aspergillus oryzae seems to have little to no effect. The latter is used in mose lactase supplements

dmart 6y ago
This is interesting. Do you know which brands are derived from each source? I wasn't able to find much information online.
- SilasHaslam 6y ago
  Source info is usually tucked away in fine print, or on the manufacturer's FAQ page, if at all. "Lactose-free" dairy products (milks and yogurts) and OTC supplements in pill form, as far as I know, use lactase derived from A. oryzae. Commercial dairy supply companies sell K. lactis in bulk. I've found one brand on Amazon (SeekingHealth) that's made with K. lactis derive lactose. Maybe they re-package the commercial size product? I've thought about buying a gallon for $1200, but that would probably last me more than a lifetime. Lactase comes from different sources and has different properties [0]. K. lactis has a neutral optimal pH, so it's better for processing dairy prior to consumption; A. oryzae has a lower optimal pH and higher heat tolerance, so it's more suitable for OTC supplements. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429307/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429307/

bil7 6y ago

this guy has some really great youtube videos, particularly enjoyed the series on building a camera to "see wifi"

foobiekr 6y ago
Agreed. I really like them... Though ... his live streams are pretty revealing. I recommend watching a few of them, as it will probably change the way you view his other content, both in the positive sense and in the negative.
- shawa_a_a 6y ago
  I’ve only watched his WiFi video, as well as his Lactose Intolerance gene therapy and felt he cane across quite positively. Are you alluding to specific negative behaviours he exhibits on stream that are edited from his videos?
  - foobiekr 6y ago
    I suggest watching a few and just drawing your own conclusions. I'm not being coy, I just think that the conclusions I drew may be pretty unfairly negative and I don't necessarily want to bias you.

freezing_coffee 6y ago

Have been a patron for some time, and discovered his channel with his lactose gene therapy video - to which he recently posted an update: https://www.youtube.com/watch?v=aoczYXJeMY4 https://www.youtube.com/watch?v=aoczYXJeMY4 . Great addition to scientific youtube.