3 ms·

Without distracting from you central point (which I very much agree with), please read the science around hydroxychloroquine, not the news. It works best taken

Without distracting from you central point (which I very much agree with), please read the science around hydroxychloroquine, not the news. It works best taken with Zinc, and early when symptoms first present.

ibarea277 6y ago
No. This has been disproven by the only good studies we have. Even with zinc and early, it has not been shown to have any effect.
- jamesrom 6y ago
  There are zero studies that disprove zinc + early has a strong effect. You are wrong. Also, the lancet study was retracted for flawed methodology, other studies show slight benefit of hydroxychloroquine. There are zero studies that show it has no effect.
  - nl 6y ago
    https://blogs.sciencemag.org/pipeline/archives/2020/06/05/the-recovery-trial-reports-on-hydroxychloroquine https://blogs.sciencemag.org/pipeline/archives/2020/06/05/th... There's no studies yet. But there aren't any preliminary results that look promising, and the only people who think it is promising also thought hydroxychloroquine was. So it's pretty unlikely it's going to do anything.
  - jupp0r 6y ago
    You can’t show that it has zero effect without indefinite numbers of patients enrolled in the study. It hasn’t shown any dramatic improvements in the studies that are there. The rest is a tradeoff between enrolling even more patients into studies to prove small improvements (or not) or to move on and spend resources on finding things that do have a major impact.
throwaway_pdp09 6y ago
Provide links to that 'science' if you're going to claim it exists, including any corroborating studies.
- drocer88 6y ago
  https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1 https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v... "This study provides the first in vivo evidence that zinc sulfate in combination with hydroxychloroquine may play a role in therapeutic management for COVID-19." https://www.sciencedirect.com/science/article/pii/S0306987720306435 https://www.sciencedirect.com/science/article/pii/S030698772... "we hypothesize that CQ/HCQ plus zinc supplementation may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy." https://www.researchgate.net/profile/Mujeeb_Shittu4/publication/340929682_Improving_the_efficacy_of_Chloroquine_and_Hydroxychloroquine_against_SARS-CoV-2_may_require_Zinc_additives_-_A_better_synergy_for_future_COVID-19_clinical_trials/links/5eca6152a6fdcc90d693f92b/Improving-the-efficacy-of-Chloroquine-and-Hydroxychlo https://www.researchgate.net/profile/Mujeeb_Shittu4/publicat... roquine-against-SARS-CoV-2-may-require-Zinc-additives-A-better-synergy-for-future-COVID-19-clinical-trials.pdf "We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the vi-rus on the affected patients and improving clinical tri-als outcome through the synergistic action of zinc and chloroquine" https://www.researchgate.net/profile/Rishad_Ahmed2/publication/340388856_Relevance_and_Role_of_Hydroxychloroquine_in_Prophylaxis_and_Therapy_of_COVID-19/links/5e862a26299bf130797459c4/Relevance-and-Role-of-Hydroxychloroquine-in-Prophylaxis-and-Therapy-of-COVID-19.pdf https://www.researchgate.net/profile/Rishad_Ahmed2/publicati... "Thirdly, hydroxychloroquine acts as an ionophoric agent for Zinc ions and thus increases the influx of Zinc ions into the cytoplasm of host target cells regardless whether the host target cells are infected or not [10]. Zinc ions adhere to the RNA dependent RNA polymerase enzyme of the virus and stops COVID-19 polymerization intracellularly." We do need follow up and repeated clinical trials.
  - pnako 6y ago
    There are already good retrospective observational studies out, like [0] [0] Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis https://www.sciencedirect.com/science/article/pii/S1477893920302817 https://www.sciencedirect.com/science/article/pii/S147789392...

ibarea277 6y ago

No. This has been disproven by the only good studies we have. Even with zinc and early, it has not been shown to have any effect.

jamesrom 6y ago
There are zero studies that disprove zinc + early has a strong effect. You are wrong. Also, the lancet study was retracted for flawed methodology, other studies show slight benefit of hydroxychloroquine. There are zero studies that show it has no effect.
- nl 6y ago
  https://blogs.sciencemag.org/pipeline/archives/2020/06/05/the-recovery-trial-reports-on-hydroxychloroquine https://blogs.sciencemag.org/pipeline/archives/2020/06/05/th... There's no studies yet. But there aren't any preliminary results that look promising, and the only people who think it is promising also thought hydroxychloroquine was. So it's pretty unlikely it's going to do anything.
- jupp0r 6y ago
  You can’t show that it has zero effect without indefinite numbers of patients enrolled in the study. It hasn’t shown any dramatic improvements in the studies that are there. The rest is a tradeoff between enrolling even more patients into studies to prove small improvements (or not) or to move on and spend resources on finding things that do have a major impact.

throwaway_pdp09 6y ago

Provide links to that 'science' if you're going to claim it exists, including any corroborating studies.

drocer88 6y ago
https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1 https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v... "This study provides the first in vivo evidence that zinc sulfate in combination with hydroxychloroquine may play a role in therapeutic management for COVID-19." https://www.sciencedirect.com/science/article/pii/S0306987720306435 https://www.sciencedirect.com/science/article/pii/S030698772... "we hypothesize that CQ/HCQ plus zinc supplementation may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy." https://www.researchgate.net/profile/Mujeeb_Shittu4/publication/340929682_Improving_the_efficacy_of_Chloroquine_and_Hydroxychloroquine_against_SARS-CoV-2_may_require_Zinc_additives_-_A_better_synergy_for_future_COVID-19_clinical_trials/links/5eca6152a6fdcc90d693f92b/Improving-the-efficacy-of-Chloroquine-and-Hydroxychlo https://www.researchgate.net/profile/Mujeeb_Shittu4/publicat... roquine-against-SARS-CoV-2-may-require-Zinc-additives-A-better-synergy-for-future-COVID-19-clinical-trials.pdf "We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the vi-rus on the affected patients and improving clinical tri-als outcome through the synergistic action of zinc and chloroquine" https://www.researchgate.net/profile/Rishad_Ahmed2/publication/340388856_Relevance_and_Role_of_Hydroxychloroquine_in_Prophylaxis_and_Therapy_of_COVID-19/links/5e862a26299bf130797459c4/Relevance-and-Role-of-Hydroxychloroquine-in-Prophylaxis-and-Therapy-of-COVID-19.pdf https://www.researchgate.net/profile/Rishad_Ahmed2/publicati... "Thirdly, hydroxychloroquine acts as an ionophoric agent for Zinc ions and thus increases the influx of Zinc ions into the cytoplasm of host target cells regardless whether the host target cells are infected or not [10]. Zinc ions adhere to the RNA dependent RNA polymerase enzyme of the virus and stops COVID-19 polymerization intracellularly." We do need follow up and repeated clinical trials.
- pnako 6y ago
  There are already good retrospective observational studies out, like [0] [0] Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis https://www.sciencedirect.com/science/article/pii/S1477893920302817 https://www.sciencedirect.com/science/article/pii/S147789392...