3 ms·
I am not a doctor but both my kids are T1D so I am quite familiar with it. This part stood out to me; > In most people with type 1 diabetes, the body’s immune
by zaroth 6y ago
I am not a doctor but both my kids are T1D so I am quite familiar with it.
This part stood out to me;
> In most people with type 1 diabetes, the body’s immune cells start destroying β-cells — which are responsible for producing the hormone insulin — in the pancreas, often suddenly. In Gnadt’s case, Hollstein suspected that the virus had destroyed his β-cells, because his blood didn’t contain the types of immune cells that typically damage the pancreatic islets where the β-cells live.
If the virus damages the islets it could suppress insulin production, but without an autoimmune response there’s reason to be hopeful that the damage is only temporary and that the pancreas can recover.
TFA says that whether the virus directly attacks cells or induces an immune response, and whether the damage is permanent or not, are both areas under active investigation.
- zaroth 6y agoI will add that it's very common for what doctors believe to be "latent" T1D to be "triggered" by a viral episode. The theory is that the body is somehow primed to have the auto-immune response, and that it is essentially inevitable, but it takes some unrelated stress/immune response to kick off the cascading failure. In that regard it wouldn't be surprising to see the typical rate of T1D diagnosis just happening to be triggered by the currently predominant virus, i.e. COVID, but in that case you would expect to see the tell-tale antibodies, and the overall incidence rate of T1D in the population would not spike.