Seemingly, most of the complex traits for which GWA is an effective methodology (a few SNPs of large effect size) have already been discovered. More and more th

Seemingly, most of the complex traits for which GWA is an effective methodology (a few SNPs of large effect size) have already been discovered. More and more these days, I’m seeing association studies that fail to yield any hits. Whether this is due to sample size, polygenicity, or some other model failure remains to be seen.