Seeing how identical individuals from literally the same cell line in an exactly identical and controlled environment sometimes give different results I don't t

Seeing how identical individuals from literally the same cell line in an exactly identical and controlled environment sometimes give different results I don't think you can ever achieve 'perfect controls' anyway. The solution is to delve deep into what things actually do (in the case of people I know, that involves a lot of live single-cell imaging and suchlike) but that's expensive.