That's unfortunately not even remotely feasible for a number of reasons. There's no effective delivery mechanism for large-scale changes, efficacy is low even w

That's unfortunately not even remotely feasible for a number of reasons. There's no effective delivery mechanism for large-scale changes, efficacy is low even when a CRISPR system does get delivered to a cell, and there can be serious issues from both on- and off-target activity. These limitations will certainly improve as the technology advances but I can't imagine that there will never be a tradeoff. I would argue that the solution to this problem is regrettably not technical.