4 ms·

Are they actually useless? I recall there was substantial controversy around studies not specifically pairing Hydroxychloroquine along with Zinc, which is neede

Are they actually useless? I recall there was substantial controversy around studies not specifically pairing Hydroxychloroquine along with Zinc, which is needed for it to be effective. I think https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1 https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v... was one of the few studies that specifically incorporated zinc. Does anyone know where that line of scientific study ended up?

adrr 6y ago
FDA pulled emergency authorization after looking at all the studies.
- garmaine 6y ago
  Which turned out to be bogus (outright fraud, probably) and retracted days later. But the FDA hasn’t reversed...
  - dajohnson89 6y ago
    what's the motive for fraudulently rejecting hydroxychloroquine here?
    - walterbell 6y ago
      HCQ is generic and sells for less than $10. Newer treatments are often more than $1000.
      - adrr 6y ago
        Are you saying the FDA is corrupt? If so are you going to hold the president accountable as the leader of executive branch? Just curious.
        garmaine 6y ago
        Not the FDA, the organization which published the flawed study.
    - Trumpi 6y ago
      Vote by mail.
pjc50 6y ago
Nobody ever convincingly explained how it was supposed to act? And whether it would be effective on other sorts of coronavirus?
- garmaine 6y ago
  Yes they have, from the onset. It was only considered BECAUSE there was a plausible mechanism. HCQ is able to transport zinc ions across cell boundaries, which is critical to getting zinc bioavailable within a cell. Zinc disrupts the viral RNA copying which is part of the replication process. So zinc + HCQ should slow down the progression of the disease by decreasing viral load. Notably most studies did not pair HCQ with zinc, and most focused on near-terminal patients for which slowing down viral replication would be too little, too late.
- walterbell 6y ago
  Here are studies of HCQ + zinc success for early treatment, https://docs.google.com/document/d/1O6Cls-Oz2ZAgJuyDbnICEGjMvQPEyM-aaXARUomR9Ww https://docs.google.com/document/d/1O6Cls-Oz2ZAgJuyDbnICEGjM...
  - phkahler 6y ago
    If I get Covid19 I plan to request that treatment. I'll doctor shop if need be. OTOH I think I already had it back in early March, but nobody really wants to test for it.
    - walterbell 6y ago
      It's also been used as a prophylactic by healthcare workers. Half-life in body is weeks.
    - vernie 6y ago
      Nobody will give you an antibody test? Do you live near a city?

adrr 6y ago

FDA pulled emergency authorization after looking at all the studies.

garmaine 6y ago
Which turned out to be bogus (outright fraud, probably) and retracted days later. But the FDA hasn’t reversed...
- dajohnson89 6y ago
  what's the motive for fraudulently rejecting hydroxychloroquine here?
  - walterbell 6y ago
    HCQ is generic and sells for less than $10. Newer treatments are often more than $1000.
    - adrr 6y ago
      Are you saying the FDA is corrupt? If so are you going to hold the president accountable as the leader of executive branch? Just curious.
      - garmaine 6y ago
        Not the FDA, the organization which published the flawed study.
  - Trumpi 6y ago
    Vote by mail.

pjc50 6y ago

Nobody ever convincingly explained how it was supposed to act? And whether it would be effective on other sorts of coronavirus?

garmaine 6y ago
Yes they have, from the onset. It was only considered BECAUSE there was a plausible mechanism. HCQ is able to transport zinc ions across cell boundaries, which is critical to getting zinc bioavailable within a cell. Zinc disrupts the viral RNA copying which is part of the replication process. So zinc + HCQ should slow down the progression of the disease by decreasing viral load. Notably most studies did not pair HCQ with zinc, and most focused on near-terminal patients for which slowing down viral replication would be too little, too late.
walterbell 6y ago
Here are studies of HCQ + zinc success for early treatment, https://docs.google.com/document/d/1O6Cls-Oz2ZAgJuyDbnICEGjMvQPEyM-aaXARUomR9Ww https://docs.google.com/document/d/1O6Cls-Oz2ZAgJuyDbnICEGjM...
- phkahler 6y ago
  If I get Covid19 I plan to request that treatment. I'll doctor shop if need be. OTOH I think I already had it back in early March, but nobody really wants to test for it.
  - walterbell 6y ago
    It's also been used as a prophylactic by healthcare workers. Half-life in body is weeks.
  - vernie 6y ago
    Nobody will give you an antibody test? Do you live near a city?