At least for: - interfacing with custom hardware From experience, that's a lot easier on Linux. As for CAD, video editing and music production - sure you do

At least for: - interfacing with custom hardware From experience, that's a lot easier on Linux. As for CAD, video editing and music production - sure you do have a point, except that in those areas the likes of Autodesk and Adobe dominate anyway and the "pro" segment of macOS/Windows users is a tiny fraction of the overall userbase, so I'd be rather surprised if that's the kind of software you can sell in decent numbers to macOS/Windows users as an indie dev.