3 ms·

The article writer totally underestimates the effort it takes to get a drug or a vaccine to the patient. "Months of intense research" have yielded at least 200

The article writer totally underestimates the effort it takes to get a drug or a vaccine to the patient. "Months of intense research" have yielded at least 200+ compounds being tested for various activities. Large consortia have formed. A lot of things are being done in parallel to speed up testing (see vaccine research). It takes time to prove efficacy: remedisivir only showed its efficacy in a 800+ people cohort. At first the time to administration was not correct: lopinavir-ritonavir were thought to be not working, but perhaps they do if given earlier in treatment, and what not. I don't know what the author's expectations are, but we're witnessing a very fast pace of drug development and testing (not without warts, of course). What did the author expect, a miracle cure in 6 months? Most of the drugs being tested at this point are repurposed: the new ones will be tested through the summer and early autumn. And there are wins like with dexamethasone, which is effective and cuts down mortality. I recommend (to the author) a thorough reading of what's going on before launching in such a pessimistic piece. Yes, we might still be in hot waters. No, it's not that we will be destroyed by this coronavirus. By the way, indications from early data from vaccine development tells us that it immunity is generated. The open questions are the duration, and the efficacy in a diverse population. But that's what trials are for. The fastest vaccine ever made took 4 years, IIRC. We're close to having results in 8 months (positive or not, the data will tell). P.S.: The cold is mainly caused by rhinoviruses. Coronaviruses only account for a small percentage of that.

redis_mlc 6y ago
> we're witnessing a very fast pace of drug development and testing Anything short of a successful human trial is ... nothing. SARS-1 in 2003 even had animal trials, but no results in humans. (Covid-19 is SARS-2.) The false hope of a vaccine or cure has caused some US governors to announce waiting for a vaccine before ending lockdown. 2022? What if that vaccine never comes? How do you base policy on mere hope?
- lbeltrame 6y ago
  > Anything short of a successful human trial is ... nothing. RECOVERY just posted their preliminary results on dexamethasone. The NIAID trials showed efficacy of remedisivir. But getting a trial right can take some time. RECOVERY started in March, and had to enroll 10,000 patients or so. A lot of trials are running at this point, it is a matter of collecting data and drawing conclusions. Antibody based therapies are probably the ones going to be the most effective, but I worry about the cost (they aren't cheap). > The false hope of a vaccine or cure has caused some US governors to announce waiting for a vaccine before ending lockdown. That is misguided as much as saying that there is no cure (yet). In fact, I'd say that most governments focused too much on vaccines and too little on pharmacological interventions. FTR, for SARS, a lot of programs were halted because it fizzled out, and so it was impossible to actually test them. For MERS though, there were vaccines in development (and still are), and that's why most of the stakeholders were this fast in getting candidates ready.
  - redis_mlc 6y ago
    It's great that you're optimistic, but neither SARS-1 (2003) nor MERS (2012) have vaccines: "The first identified case occurred in 2012 in Saudi Arabia and most cases have occurred in the Arabian Peninsula.[2][7] About 2,500 cases have been reported as of January 2020.[4] About 35% of those who are diagnosed with the disease die from it.[2] Larger outbreaks have occurred in South Korea in 2015 and in Saudi Arabia in 2018" https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome https://en.wikipedia.org/wiki/Middle_East_respiratory_syndro...

redis_mlc 6y ago

> we're witnessing a very fast pace of drug development and testing Anything short of a successful human trial is ... nothing. SARS-1 in 2003 even had animal trials, but no results in humans. (Covid-19 is SARS-2.) The false hope of a vaccine or cure has caused some US governors to announce waiting for a vaccine before ending lockdown. 2022? What if that vaccine never comes? How do you base policy on mere hope?

lbeltrame 6y ago
> Anything short of a successful human trial is ... nothing. RECOVERY just posted their preliminary results on dexamethasone. The NIAID trials showed efficacy of remedisivir. But getting a trial right can take some time. RECOVERY started in March, and had to enroll 10,000 patients or so. A lot of trials are running at this point, it is a matter of collecting data and drawing conclusions. Antibody based therapies are probably the ones going to be the most effective, but I worry about the cost (they aren't cheap). > The false hope of a vaccine or cure has caused some US governors to announce waiting for a vaccine before ending lockdown. That is misguided as much as saying that there is no cure (yet). In fact, I'd say that most governments focused too much on vaccines and too little on pharmacological interventions. FTR, for SARS, a lot of programs were halted because it fizzled out, and so it was impossible to actually test them. For MERS though, there were vaccines in development (and still are), and that's why most of the stakeholders were this fast in getting candidates ready.
- redis_mlc 6y ago
  It's great that you're optimistic, but neither SARS-1 (2003) nor MERS (2012) have vaccines: "The first identified case occurred in 2012 in Saudi Arabia and most cases have occurred in the Arabian Peninsula.[2][7] About 2,500 cases have been reported as of January 2020.[4] About 35% of those who are diagnosed with the disease die from it.[2] Larger outbreaks have occurred in South Korea in 2015 and in Saudi Arabia in 2018" https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome https://en.wikipedia.org/wiki/Middle_East_respiratory_syndro...