Not really the same thing but I'm blood type O- and do the "Power Red" donation at Red Cross events. I have two units of blood taken out and the red cells and p

Not really the same thing but I'm blood type O- and do the "Power Red" donation at Red Cross events. I have two units of blood taken out and the red cells and plasma are separated so the plasma can be returned along with saline to make up the difference in volume. I don't notice much of a difference besides feeling a little cold since the saline is at room temperature. However in that case I believe I'd only have ~10% of my blood volume replaced with saline.