5 ms·
If you are interested in seeing a biological study "proving" ADHD, here are two. This meta-analysis from 2010 found a link between duplication of specific genes
by caleb-allen 6y ago
If you are interested in seeing a biological study "proving" ADHD, here are two. This meta-analysis from 2010 found a link between duplication of specific genes and ADHD [0]. This 2016 study [1] links the precise gene duplication mechanism with irregular neurogenesis, and subsequently hyperactive behavior.
[0]: Williams NM, Zaharieva I, Martin A, et al. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet. 2010;376(9750):1401-1408. doi:10.1016/S0140-6736(10)61109-9 https://pubmed.ncbi.nlm.nih.gov/20888040/ https://pubmed.ncbi.nlm.nih.gov/20888040/
[1]: Fujitani, M., Zhang, S., Fujiki, R. et al. A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling. Mol Psychiatry 22, 364–374 (2017). https://doi.org/10.1038/mp.2016.106 https://doi.org/10.1038/mp.2016.106