4 ms·

More informative article here: https://www.statnews.com/2020/06/16/major-study-finds-common-steroid-reduces-deaths-among-patients-with-severe-covid-19/ https:/

by aazaa 6y ago

More informative article here: https://www.statnews.com/2020/06/16/major-study-finds-common-steroid-reduces-deaths-among-patients-with-severe-covid-19/ https://www.statnews.com/2020/06/16/major-study-finds-common... The problem is that there is little more than a press announcement at this point. There are no data. There is no paper. There are no details to consider. We've seen this movie before, and it's gone badly (remdesivir, hydroxychloroquine). Safe and effective drugs require copious details, and you'll find none of them here.

selimthegrim 6y ago
What's bad about remdesivir?
- SmkyMt 6y ago
  "The most common adverse effects in studies of remdesivir for COVID‑19 include respiratory failure and organ impairment..." —wikipedia entry
  - delecti 6y ago
    That sounds more like "sometimes it doesn't work" than "sometimes it extra kills you".
- WhompingWindows 6y ago
  It's simply not that effective, it has a very small treatment effect and isn't a great tool, but it's certainly much more justifiable than hydroxychloroquine, which took much of the oxygen out of the room when POTUS and the GOP hyped it FAR beyond its statistically shown merits.
  - amluto 6y ago
    Also: it has serious manufacturability issues, and it can only be administered by IV. It’s entirely plausible that giving remdesivir to COVID-19 patients when they first show symptoms would make a big difference, but it’s impractical.
WhompingWindows 6y ago
We haven't seen this movie before, this is much more promising with much larger sample sizes. PLUS, this EXACT study (RECOVERY) found that HCQ was not effective for severe patients. While I believe in peer review and publication, these are Oxford University researchers using sample size of over 2000 COVID patients in the treatment arm, so it's FAR beyond "this movie before" where HCQ studies with a couple dozen patients were hyping far beyond the statistical merit.
chimprich 6y ago
Slightly more detail in the press release: https://www.recoverytrial.net/files/recovery_dexamethasone_statement_160620_v2final.pdf https://www.recoverytrial.net/files/recovery_dexamethasone_s... You're being unreasonably negative. It's a very positive study in one of the world's biggest trials. It would be unethical not to release the results as soon as possible. I'm sure more details will be released imminently.
capkutay 6y ago
This is a very well-respected, well-known multi-arm trial 10x the size of US govt (NIAID) studies. It's 6x larger than Dr. Fauci's remdesivir study. It's highlighting a cheap, generic drug; nothing like Remdesivir. It would be unethical to delay this announcement, especially when most hospitals are already supplied with the treatment.

by aazaa 6y ago

selimthegrim 6y ago

What's bad about remdesivir?

SmkyMt 6y ago
"The most common adverse effects in studies of remdesivir for COVID‑19 include respiratory failure and organ impairment..." —wikipedia entry
- delecti 6y ago
  That sounds more like "sometimes it doesn't work" than "sometimes it extra kills you".
WhompingWindows 6y ago
It's simply not that effective, it has a very small treatment effect and isn't a great tool, but it's certainly much more justifiable than hydroxychloroquine, which took much of the oxygen out of the room when POTUS and the GOP hyped it FAR beyond its statistically shown merits.
- amluto 6y ago
  Also: it has serious manufacturability issues, and it can only be administered by IV. It’s entirely plausible that giving remdesivir to COVID-19 patients when they first show symptoms would make a big difference, but it’s impractical.

WhompingWindows 6y ago

We haven't seen this movie before, this is much more promising with much larger sample sizes. PLUS, this EXACT study (RECOVERY) found that HCQ was not effective for severe patients. While I believe in peer review and publication, these are Oxford University researchers using sample size of over 2000 COVID patients in the treatment arm, so it's FAR beyond "this movie before" where HCQ studies with a couple dozen patients were hyping far beyond the statistical merit.

chimprich 6y ago

Slightly more detail in the press release: https://www.recoverytrial.net/files/recovery_dexamethasone_statement_160620_v2final.pdf https://www.recoverytrial.net/files/recovery_dexamethasone_s... You're being unreasonably negative. It's a very positive study in one of the world's biggest trials. It would be unethical not to release the results as soon as possible. I'm sure more details will be released imminently.

capkutay 6y ago

This is a very well-respected, well-known multi-arm trial 10x the size of US govt (NIAID) studies. It's 6x larger than Dr. Fauci's remdesivir study. It's highlighting a cheap, generic drug; nothing like Remdesivir. It would be unethical to delay this announcement, especially when most hospitals are already supplied with the treatment.