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What does this have to do with Dexamethasone? They might have made that mistake. Humans make mistakes. afair 30% of all human death in hospital are caused by i

What does this have to do with Dexamethasone? They might have made that mistake. Humans make mistakes. afair 30% of all human death in hospital are caused by incompetence or a mistake.

jcahill 6y ago
>What does this have to do with Dexamethasone? - Shared personnel are hot on the heels of a deeply dubious result and attempted damage control that has involved an outlandish claim of misrepresentation in an interview. - This has all the right smells so far to expect further questionable research practices. - A press release was prioritized over a preprint, even though the authors absolutely know that readily-available drugs will be taken up as primary treatment methods as soon as this news meme spreads. They have given the research community zero time to double-check. - Wildly sensationalist claims made to the press. >They might have made that mistake. This wasn't a simple mistake. Look at ice9's exploration on twitter (see [2]). The whole thing's quite damning.
sydd 6y ago
UK covid handlig/research is full of grossly incompetent things. First they went for herd immunity because their flawed models predicted that it'll be okay, then they backtracked the last moment. Then they announced that their vaccine will be ready by fall when every other respected scientist said that it'll take a year. Something if off to me with the UK academic standards in medicine.
- Someone 6y ago
  I don’t follow British corona policy closely, but as far as I can tell, the they in those sentences, in most cases, were politicians (that also _had_ to make choices based on very much incomplete information, but that’s a different subject). You can’t blame UK academic standards for that.
- rsynnott 6y ago
  The herd immunity thing was the UK’s admittedly shambolic government; scientists and the medical profession immediately raised concerns. And I don’t think anyone’s saying the Oxford candidate vaccine will actually be available and approved for mass use this year?
  - chimprich 6y ago
    > And I don’t think anyone’s saying the Oxford candidate vaccine will actually be available and approved for mass use this year? That genuinely is the goal. The current aim is October I believe. A quote from their website says "deliveries starting by the end of 2020". https://www.ovg.ox.ac.uk/news/astrazeneca-to-supply-europe-with-up-to-400-million-doses-of-oxford-university2019s-vaccine-at-no-profit https://www.ovg.ox.ac.uk/news/astrazeneca-to-supply-europe-w... That assumes everything goes well, which is a big if, but seems possible. The fact we've had no bad news so far despite the advanced trials is good news.
    - jcahill 6y ago
      Theirs is AZD1222, fka ChAdOx1 nCoV-19. It has goofy delivery dates for multiple markets. We've had no bad news because it's a simple design that bets on robust immune response doing the job. It's in contractors' interest to push ferocious timetables regardless of whether this vaccine strategy is viable: if it isn't, payouts are still secured prior to evidence of this coming to light, so they don't get stuck holding the bag. If it is, they're getting to market by next flu season. https://www.precisionvaccinations.com/vaccines/azd1222-sars-cov-2-vaccine https://www.precisionvaccinations.com/vaccines/azd1222-sars-...
      - chimprich 6y ago
        It's in everyone's interest to make any vaccine available as soon as possible if shown to be both safe and efficacious. The vaccine is being produced at no-profit: https://www.precisionvaccinations.com/400-million-coronavirus-vaccine-doses-supplied-no-profit https://www.precisionvaccinations.com/400-million-coronaviru... > We've had no bad news because it's a simple design That makes no sense. We will have news if it fails to stop people getting badly ill, in which case they'd have to go back to the drawing board.

What does this have to do with Dexamethasone? They might have made that mistake. Humans make mistakes. afair 30% of all human death in hospital are caused by incompetence or a mistake.

jcahill 6y ago

>What does this have to do with Dexamethasone? - Shared personnel are hot on the heels of a deeply dubious result and attempted damage control that has involved an outlandish claim of misrepresentation in an interview. - This has all the right smells so far to expect further questionable research practices. - A press release was prioritized over a preprint, even though the authors absolutely know that readily-available drugs will be taken up as primary treatment methods as soon as this news meme spreads. They have given the research community zero time to double-check. - Wildly sensationalist claims made to the press. >They might have made that mistake. This wasn't a simple mistake. Look at ice9's exploration on twitter (see [2]). The whole thing's quite damning.

sydd 6y ago

UK covid handlig/research is full of grossly incompetent things. First they went for herd immunity because their flawed models predicted that it'll be okay, then they backtracked the last moment. Then they announced that their vaccine will be ready by fall when every other respected scientist said that it'll take a year. Something if off to me with the UK academic standards in medicine.

Someone 6y ago
I don’t follow British corona policy closely, but as far as I can tell, the they in those sentences, in most cases, were politicians (that also _had_ to make choices based on very much incomplete information, but that’s a different subject). You can’t blame UK academic standards for that.
rsynnott 6y ago
The herd immunity thing was the UK’s admittedly shambolic government; scientists and the medical profession immediately raised concerns. And I don’t think anyone’s saying the Oxford candidate vaccine will actually be available and approved for mass use this year?
- chimprich 6y ago
  > And I don’t think anyone’s saying the Oxford candidate vaccine will actually be available and approved for mass use this year? That genuinely is the goal. The current aim is October I believe. A quote from their website says "deliveries starting by the end of 2020". https://www.ovg.ox.ac.uk/news/astrazeneca-to-supply-europe-with-up-to-400-million-doses-of-oxford-university2019s-vaccine-at-no-profit https://www.ovg.ox.ac.uk/news/astrazeneca-to-supply-europe-w... That assumes everything goes well, which is a big if, but seems possible. The fact we've had no bad news so far despite the advanced trials is good news.
  - jcahill 6y ago
    Theirs is AZD1222, fka ChAdOx1 nCoV-19. It has goofy delivery dates for multiple markets. We've had no bad news because it's a simple design that bets on robust immune response doing the job. It's in contractors' interest to push ferocious timetables regardless of whether this vaccine strategy is viable: if it isn't, payouts are still secured prior to evidence of this coming to light, so they don't get stuck holding the bag. If it is, they're getting to market by next flu season. https://www.precisionvaccinations.com/vaccines/azd1222-sars-cov-2-vaccine https://www.precisionvaccinations.com/vaccines/azd1222-sars-...
    - chimprich 6y ago
      It's in everyone's interest to make any vaccine available as soon as possible if shown to be both safe and efficacious. The vaccine is being produced at no-profit: https://www.precisionvaccinations.com/400-million-coronavirus-vaccine-doses-supplied-no-profit https://www.precisionvaccinations.com/400-million-coronaviru... > We've had no bad news because it's a simple design That makes no sense. We will have news if it fails to stop people getting badly ill, in which case they'd have to go back to the drawing board.