Try Fedora. It comes with vanilla GNOME by default, and also has variants (they call them "spins") with KDE Plasma, XFCE, LXQT, MATE, Cinnamon, LXDE and even SO

Try Fedora. It comes with vanilla GNOME by default, and also has variants (they call them "spins") with KDE Plasma, XFCE, LXQT, MATE, Cinnamon, LXDE and even SOAS Desktop. Most software have packages for Fedora, so for a normal person it should "just work".