You can do something like this on Linux: inotifywait -m myfile.py -e 'CLOSE_WRITE' | while read line; do python3 myfile.py; done It will be more resp

You can do something like this on Linux: inotifywait -m myfile.py -e 'CLOSE_WRITE' | while read line; do python3 myfile.py; done It will be more responsive than a busy while-sleep loop.