4 ms·

My personal empirical research agrees with the headline.

by spurdoman77 6y ago

sneak 6y ago
> Six of the sheep were given a single higher dose of ketamine, 24mg/kg. This is at the high end of the anaesthetic range. Initially, the same response was seen as with a lower dose. But within two minutes of administering the drug, the brain activity of five of these six sheep stopped completely, one of them for several minutes - a phenomenon that has never been seen before. You have taken 24mg/kg of ketamine before? I find that nearly impossible to believe. Approximately 15% of that dosage causes mammals to lose consciousness.
- codetrotter 6y ago
  What would happen to a human taking such a big dose? Brain damage? Death? Permanent coma? And would the outcome be the same even if monitored by healthcare professionals? Or would they be able to stop the person from taking damage from it?
  - Johnjonjoan 6y ago
    "Ketamine abusers are known to take doses many times higher than those given to the sheep in this research. It is also likely that progressively higher doses have to be taken to get the same effect. The researchers say that such high doses can cause liver damage, may stop the heart, and be fatal."
    - ketamine__ 6y ago
      It is _really_ hard to find a fatality attributed to ketamine. Recreational users are known to take heroic doses. This sounds like pure speculation.
- unfunco 6y ago
  In one go definitely, but for a 70kg person that's 1.6g, 1g of Ketamine is ~£10 in the United Kingdom, it's really not that out of the ordinary that someone would take 1-3g during the course of an evening.
  - GordonS 6y ago
    That would be intranasally - not by IV. You get near 100% bioavailability by the IV route, a lot less by the nasal route. Also, the bags of ketamine you buy on the street are not 100% ketamine. And for most people who do a gram of street ket over an evening, they are doing small bumps over a periods of hours, not doing it all in one go.

4 ms·

My personal empirical research agrees with the headline.

by spurdoman77 6y ago

My personal empirical research agrees with the headline.

sneak 6y ago
> Six of the sheep were given a single higher dose of ketamine, 24mg/kg. This is at the high end of the anaesthetic range. Initially, the same response was seen as with a lower dose. But within two minutes of administering the drug, the brain activity of five of these six sheep stopped completely, one of them for several minutes - a phenomenon that has never been seen before. You have taken 24mg/kg of ketamine before? I find that nearly impossible to believe. Approximately 15% of that dosage causes mammals to lose consciousness.
- codetrotter 6y ago
  What would happen to a human taking such a big dose? Brain damage? Death? Permanent coma? And would the outcome be the same even if monitored by healthcare professionals? Or would they be able to stop the person from taking damage from it?
  - Johnjonjoan 6y ago
    "Ketamine abusers are known to take doses many times higher than those given to the sheep in this research. It is also likely that progressively higher doses have to be taken to get the same effect. The researchers say that such high doses can cause liver damage, may stop the heart, and be fatal."
    - ketamine__ 6y ago
      It is _really_ hard to find a fatality attributed to ketamine. Recreational users are known to take heroic doses. This sounds like pure speculation.
- unfunco 6y ago
  In one go definitely, but for a 70kg person that's 1.6g, 1g of Ketamine is ~£10 in the United Kingdom, it's really not that out of the ordinary that someone would take 1-3g during the course of an evening.
  - GordonS 6y ago
    That would be intranasally - not by IV. You get near 100% bioavailability by the IV route, a lot less by the nasal route. Also, the bags of ketamine you buy on the street are not 100% ketamine. And for most people who do a gram of street ket over an evening, they are doing small bumps over a periods of hours, not doing it all in one go.