3 ms·
Reversing age: dual species measurement of epigenetic age with a single clock
- sanqui 6y agoBreakdown by David Sinclair in this Twitter thread: https://twitter.com/davidasinclair/status/1259912928695857152 https://twitter.com/davidasinclair/status/125991292869585715... Highlight: >The result is so literally incredible that even the first author, Prof. Steve Horvath, didn't believe it at first. I suggested he check if the rats were mixed up, but he assured me he checked their genomes. The rats weren't mixed up and the data is the data. >Using the final versions of their epigenetic clocks the reversal was: liver 75%, blood 66%, heart 57%, hypothalamus 19%. Average rejuvenation across four tissues was 54.2%. This is astounding. >What else did they see? Accumulation of fat in old tissues was greatly reduced. All health-related blood biomarkers they assessed (lipids, liver function, blood cells) "were altered towards the values of young rats, without exception."