Yes, I have several pis that boot from an sd card and then all of the file systems get mounted over NFS. The sd card only needs to be read from once every few

Yes, I have several pis that boot from an sd card and then all of the file systems get mounted over NFS. The sd card only needs to be read from once every few weeks/months when it boots. Even if it does wear out, storing all the data on NFS (or a usb drive) makes it a lot less worrying.