I mean how my head twists and turns relative to my body/keyboard/mouse throughout the day. So, for example, a primary monitor in front and two secondary monito

I mean how my head twists and turns relative to my body/keyboard/mouse throughout the day. So, for example, a primary monitor in front and two secondary monitors to the left can be problematic for me - my main content might be front and center, but constantly looking off to the left only, and not the right, causes problems. Balance it with another monitor or two on the right - and moving content over there as well - and I won't have any issues, even if I'm still using the leftmost monitor some. But then, I can cause problems with that same setup - if for example I have only the leftmost monitor(s) connected to a Mac Mini, and end up doing a bunch of iOS/OS X dev/porting/debugging in a row. When I first had problems, I was using Synergy - I stopped doing that as much in favor of a second keyboard/mouse, or shelling into that machine (despite it being on my desk!)